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<p>Skin trauma, particularly chronic non-healing wounds, imposes significant economic and physical burdens on patients and their families. A defining feature of these wounds is persistent dysregulated inflammation, with macrophage efferocytosis playing a critical role. Efferocytosis—the programmed removal of apoptotic cells (ACs) by macrophages—is vital for resolving inflammation and facilitating tissue repair. In chronic wounds associated with systemic diseases such as diabetes, impaired macrophage efferocytosis hinders AC clearance, leading to prolonged inflammation and delayed healing. This review focuses on the molecular mechanisms regulating macrophage efferocytosis during inflammation and discusses clinical strategies to improve the healing of chronic wounds.</p><p></p>

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Macrophage efferocytosis promotes inflammation resolution and accelerates wound healing

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月6日

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  • Jia Gao,
  • Dong Zhu,
  • Jian Wang,
  • Malak Ihtisham Ullah Khan,
  • Aijun Zhang,
  • Xiaokang Wen,
  • Qiang Li,
  • Peisheng Jin,
  • Caiqi Shen

摘要

Skin trauma, particularly chronic non-healing wounds, imposes significant economic and physical burdens on patients and their families. A defining feature of these wounds is persistent dysregulated inflammation, with macrophage efferocytosis playing a critical role. Efferocytosis—the programmed removal of apoptotic cells (ACs) by macrophages—is vital for resolving inflammation and facilitating tissue repair. In chronic wounds associated with systemic diseases such as diabetes, impaired macrophage efferocytosis hinders AC clearance, leading to prolonged inflammation and delayed healing. This review focuses on the molecular mechanisms regulating macrophage efferocytosis during inflammation and discusses clinical strategies to improve the healing of chronic wounds.