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<p>Synaptic cell adhesion molecules (SAMs) are essential for axon pathfinding and synaptic establishment during neurodevelopment, bridging the pre- and postsynaptic compartments across the synaptic cleft. While this function is well established, recent evidence has shown these proteins also exert key neuronal functions throughout the neuron’s life, regulating neuronal communication at mature synapses. Given these novel roles, SAMs are emerging as important elements relating to mental health and as significant contributors to age-related diseases, such as neurodegenerative disorders. For insight into this emerging role of SAMs, we focused on three pivotal regulator families of the central nervous system: Neurexins, Ephrin Receptors, and N-cadherins.</p>

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Neurexins, Ephrin receptors, and N-cadherin signaling as emerging mechanisms in synaptic dysfunction and neurodegenerative diseases

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月17日

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  • João Gonçalves-Martins,
  • Carlos Cação,
  • Joana S. Ferreira

摘要

Synaptic cell adhesion molecules (SAMs) are essential for axon pathfinding and synaptic establishment during neurodevelopment, bridging the pre- and postsynaptic compartments across the synaptic cleft. While this function is well established, recent evidence has shown these proteins also exert key neuronal functions throughout the neuron’s life, regulating neuronal communication at mature synapses. Given these novel roles, SAMs are emerging as important elements relating to mental health and as significant contributors to age-related diseases, such as neurodegenerative disorders. For insight into this emerging role of SAMs, we focused on three pivotal regulator families of the central nervous system: Neurexins, Ephrin Receptors, and N-cadherins.