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<p>Characterizing cortical laminar microstructure is essential for understanding the organization of the human brain. Leveraging the next-generation Connectome MRI scanner (maximum gradient strength=500mT/m, slew rate=600 T/m/s), we characterized in vivo cortical laminar cytoarchitecture and myeloarchitecture through cortical depth-dependent analyses of soma and neurite density imaging (SANDI) metrics derived from 1 mm diffusion MRI generated using a super-resolution technique. SANDI revealed distinct laminar profiles: intra-soma signal fraction peaked at ~55% cortical depth, while the intra-neurite signal fraction increased toward deeper cortical layers, consistent with known histological patterns. The visual cortex showed higher intra-soma signal fraction than the motor cortex, particularly in deeper layers. Intra-soma signal fraction correlated positively with cortical curvature in superficial layers and negatively in deeper layers, indicating layer-specific relationships between cortical microstructure and geometry. These findings demonstrate the feasibility of noninvasive mapping of laminar architecture, offering a potential in vivo surrogate for histology and enabling future studies of cortical laminar organization using high-performance gradient MRI.</p><p></p>

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Visualizing cortical laminar architecture in the living human brain using next-generation ultra-high-gradient diffusion MRI

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月23日

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  • Hansol Lee,
  • Yixin Ma,
  • Kwok-Shing Chan,
  • Eva A. Krijnen,
  • Laleh Eskandarian,
  • Aneri Bhatt,
  • Julianna Gerold,
  • Mirsad Mahmutovic,
  • Oula Puonti,
  • Xiangrui Zeng,
  • Lucas Jacob Deden Binder,
  • Bruce Fischl,
  • Boris Keil,
  • Gabriel Ramos-Llordén,
  • Eric C. Klawiter,
  • Hong-Hsi Lee,
  • Susie Y. Huang

摘要

Characterizing cortical laminar microstructure is essential for understanding the organization of the human brain. Leveraging the next-generation Connectome MRI scanner (maximum gradient strength=500mT/m, slew rate=600 T/m/s), we characterized in vivo cortical laminar cytoarchitecture and myeloarchitecture through cortical depth-dependent analyses of soma and neurite density imaging (SANDI) metrics derived from 1 mm diffusion MRI generated using a super-resolution technique. SANDI revealed distinct laminar profiles: intra-soma signal fraction peaked at ~55% cortical depth, while the intra-neurite signal fraction increased toward deeper cortical layers, consistent with known histological patterns. The visual cortex showed higher intra-soma signal fraction than the motor cortex, particularly in deeper layers. Intra-soma signal fraction correlated positively with cortical curvature in superficial layers and negatively in deeper layers, indicating layer-specific relationships between cortical microstructure and geometry. These findings demonstrate the feasibility of noninvasive mapping of laminar architecture, offering a potential in vivo surrogate for histology and enabling future studies of cortical laminar organization using high-performance gradient MRI.