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<p>The nematode <i>Ditylenchus destructor</i> comprises multiple haplotypes with distinct host preferences, while the genetic basis remains unclear. We generate three genomes (Haplotypes A, B, and C) using hybrid assembly and conduct comparative analysis with two published Haplotype A genomes. Integrating haplotype-resolved phylogeny, whole-genome alignments, functional annotation, orthogroup profiling, and secretome analysis shows Haplotypes B and C are more similar to each other than to Haplotype A. We identify several key genomic differences that may underlie host adaptation: Haplotype A features expanded chemosensory GPCR repertoires and GH31 glycoside hydrolases. Haplotype B possesses an abundance of cytochrome P450 domain proteins and secretory pectate lyases. Haplotype C harbors more genes encoding NADPH reductases, oxidoreductases, ABC transporters, secreted animal haem peroxidases, C-type lectins, and Astacins. We propose that these genomic variations facilitate the nematode’s adaptation to different host plants. Collectively, our findings establish a genomic framework for understanding host adaptation in <i>D. destructor</i>.</p>

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Comparative genomics of different haplotypes in Ditylenchus destructor provides insights into their host preferences

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月14日

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  • Zhengyang Zhao,
  • Hongxia Zhang,
  • Jiayu Wang,
  • Ning Luo,
  • Huixia Li,
  • Runmao Lin,
  • Bingyan Xie

摘要

The nematode Ditylenchus destructor comprises multiple haplotypes with distinct host preferences, while the genetic basis remains unclear. We generate three genomes (Haplotypes A, B, and C) using hybrid assembly and conduct comparative analysis with two published Haplotype A genomes. Integrating haplotype-resolved phylogeny, whole-genome alignments, functional annotation, orthogroup profiling, and secretome analysis shows Haplotypes B and C are more similar to each other than to Haplotype A. We identify several key genomic differences that may underlie host adaptation: Haplotype A features expanded chemosensory GPCR repertoires and GH31 glycoside hydrolases. Haplotype B possesses an abundance of cytochrome P450 domain proteins and secretory pectate lyases. Haplotype C harbors more genes encoding NADPH reductases, oxidoreductases, ABC transporters, secreted animal haem peroxidases, C-type lectins, and Astacins. We propose that these genomic variations facilitate the nematode’s adaptation to different host plants. Collectively, our findings establish a genomic framework for understanding host adaptation in D. destructor.