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<p>Understanding the network topology of a cluster of diverse neurons acting in concert requires a detailed expression map of ligand–receptor pairs involved in cell–cell communication. The neuropeptide arginine vasopressin (AVP) and signaling mediated by its cognate receptor V1a have been implicated in dorsal-to-ventral regional communication in the suprachiasmatic nucleus (SCN), a cluster of neurons that acts in concert to generate daily rhythms in behavior and physiology. Here, we show that among vasoactive intestinal peptide (VIP)-ergic neurons in the ventral SCN only a small subpopulation expresses <i>V1a</i>, and we demonstrate the requirement of <i>V1a</i> in these VIP neurons for maintaining the robustness of the circadian clock using a jet-lag paradigm. Notably, we found that <i>V1a</i> expression appears to be minimal in the other major ventral neuronal population expressing gastrin-releasing peptide (GRP). The identified heterogeneity between VIP and GRP neurons, and among VIP neurons, provides a basic map for understanding the cryptic network structure from dorsal AVP neurons to receiver ventral SCN.</p><p></p>

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Heterogeneity between VIP and GRP neurons underlies AVP receptor signaling in the mouse suprachiasmatic nucleus

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月12日

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  • Huihua Zhou,
  • Daichi Moriyasu,
  • Sui-Wen Hsiao,
  • Yoshiaki Yamaguchi,
  • Morio Azuma,
  • Taka-aki Koshimizu,
  • Keiichi Itoi,
  • Kenji Sakimura,
  • William J. Schwartz,
  • Hitoshi Okamura,
  • Emi Hasegawa,
  • Masao Doi

摘要

Understanding the network topology of a cluster of diverse neurons acting in concert requires a detailed expression map of ligand–receptor pairs involved in cell–cell communication. The neuropeptide arginine vasopressin (AVP) and signaling mediated by its cognate receptor V1a have been implicated in dorsal-to-ventral regional communication in the suprachiasmatic nucleus (SCN), a cluster of neurons that acts in concert to generate daily rhythms in behavior and physiology. Here, we show that among vasoactive intestinal peptide (VIP)-ergic neurons in the ventral SCN only a small subpopulation expresses V1a, and we demonstrate the requirement of V1a in these VIP neurons for maintaining the robustness of the circadian clock using a jet-lag paradigm. Notably, we found that V1a expression appears to be minimal in the other major ventral neuronal population expressing gastrin-releasing peptide (GRP). The identified heterogeneity between VIP and GRP neurons, and among VIP neurons, provides a basic map for understanding the cryptic network structure from dorsal AVP neurons to receiver ventral SCN.