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<p>Visual perception appears largely stable in time. However, psychophysical studies have revealed that low frequency (0.5 – 7 Hz) oscillatory dynamics can modulate perception and have been linked to various cognitive states and functions. Neither the contribution of waves around 5 Hz (theta or alpha-like) to cortical activity nor their impact during aberrant brain states have been resolved at high spatiotemporal scales. Here, using cortex-wide population voltage imaging in awake mice, we found that bouts of 5-Hz oscillations in the visual cortex are accompanied by similar oscillations in the retrosplenial cortex, occurring both spontaneously and evoked by visual stimulation. Injection of psychotropic 5-HT2AR agonist induced a significant increase in spontaneous 5-Hz oscillations, and also increased the power, occurrence probability and temporal persistence of visually evoked 5-Hz oscillations. This modulation of 5-Hz oscillations in both cortical areas indicates a strengthening of top-down control of perception, supporting an underlying mechanism of perceptual filling and visual hallucinations.</p><p></p>

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Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月12日

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  • Callum M. White,
  • Zohre Azimi,
  • Robert Staadt,
  • Chenchen Song,
  • Thomas Knöpfel,
  • Dirk Jancke

摘要

Visual perception appears largely stable in time. However, psychophysical studies have revealed that low frequency (0.5 – 7 Hz) oscillatory dynamics can modulate perception and have been linked to various cognitive states and functions. Neither the contribution of waves around 5 Hz (theta or alpha-like) to cortical activity nor their impact during aberrant brain states have been resolved at high spatiotemporal scales. Here, using cortex-wide population voltage imaging in awake mice, we found that bouts of 5-Hz oscillations in the visual cortex are accompanied by similar oscillations in the retrosplenial cortex, occurring both spontaneously and evoked by visual stimulation. Injection of psychotropic 5-HT2AR agonist induced a significant increase in spontaneous 5-Hz oscillations, and also increased the power, occurrence probability and temporal persistence of visually evoked 5-Hz oscillations. This modulation of 5-Hz oscillations in both cortical areas indicates a strengthening of top-down control of perception, supporting an underlying mechanism of perceptual filling and visual hallucinations.