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<p>Removing cold water from wet fur or feathers can help endothermic animals to thermoregulate. The “wet dog shakes” (WDS) behavior has been largely characterized in mammals but to a much lesser extent in birds. Although it is known that TRPM8 is the main molecular transducer of low temperature in mammals, it is not clear if wetness-induced shaking in furred and feathered animals is dependent on TRPM8. Here, we show that a novel TRPM8 agonist induces WDS in rodents, and also in birds, similar to the shaking behavior evoked by water-spraying. Furthermore, the WDS onset depends on TRPM8, as we show in water-sprayed mice. Overall, our results provide multiple evidence for a TRPM8 dependence of WDS behaviors in all tested species. These suggest that a convergent evolution selected similar shaking behaviors to expel water from fur and feathers, with TRPM8 being involved in cold wetness sensing in both mammals and birds.</p>

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Cold- and TRPM8-dependent shaking in mammals and birds

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月20日

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  • Tudor Selescu,
  • Ramona-Andreea Bivoleanu,
  • Violeta-Maria Caragea,
  • Mirela Iodi Carstens,
  • Alexandra Manolache,
  • Debora-Elena Huțanu,
  • Rathej Meerupally,
  • Edward T. Wei,
  • Earl Carstens,
  • Katharina Zimmermann,
  • Alexandru Babes

摘要

Removing cold water from wet fur or feathers can help endothermic animals to thermoregulate. The “wet dog shakes” (WDS) behavior has been largely characterized in mammals but to a much lesser extent in birds. Although it is known that TRPM8 is the main molecular transducer of low temperature in mammals, it is not clear if wetness-induced shaking in furred and feathered animals is dependent on TRPM8. Here, we show that a novel TRPM8 agonist induces WDS in rodents, and also in birds, similar to the shaking behavior evoked by water-spraying. Furthermore, the WDS onset depends on TRPM8, as we show in water-sprayed mice. Overall, our results provide multiple evidence for a TRPM8 dependence of WDS behaviors in all tested species. These suggest that a convergent evolution selected similar shaking behaviors to expel water from fur and feathers, with TRPM8 being involved in cold wetness sensing in both mammals and birds.