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<p>The stable structure and growth cycle of human hair enables the accumulation of both endogenous and exogenous compounds, making hair an ideal matrix for long-term profiling. However, its exact molecular composition, shaped by root-to-tip variations, remains poorly understood. Here, we present a metabolome and lipidome atlas of human hair originating from a healthy cohort. The Human Hair Atlas maps over 1200 unique molecular species and highlights compounds prone to significant longitudinal variations. Metabolite and lipid levels vary by up to 50% along the length of the hair, underscoring the importance of accounting for segmental differences. We categorized 122 molecules as exposome-related compounds, primarily from personal care products, facilitating biological interpretation. The Human Hair Atlas is publicly accessible (<a href="https://metabolomics.cloud/hair/">https://metabolomics.cloud/hair/</a>), providing a resource to stimulate research in hair metabolomics, lipidomics, and exposomics, and to explore the potential of hair as a complementary matrix in clinical studies.</p>

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Metabolomic and lipidomic atlas of human hair across its length

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月25日

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  • Maria van de Lavoir,
  • Yuanye Chi,
  • Ting Zeng,
  • Rani Robeyns,
  • Maria del Mar Delgado Povedano,
  • Leen Jacobs,
  • Celine Gys,
  • Hugo Neels,
  • Shuzhao Li,
  • Alexander L. N. van Nuijs,
  • Adrian Covaci

摘要

The stable structure and growth cycle of human hair enables the accumulation of both endogenous and exogenous compounds, making hair an ideal matrix for long-term profiling. However, its exact molecular composition, shaped by root-to-tip variations, remains poorly understood. Here, we present a metabolome and lipidome atlas of human hair originating from a healthy cohort. The Human Hair Atlas maps over 1200 unique molecular species and highlights compounds prone to significant longitudinal variations. Metabolite and lipid levels vary by up to 50% along the length of the hair, underscoring the importance of accounting for segmental differences. We categorized 122 molecules as exposome-related compounds, primarily from personal care products, facilitating biological interpretation. The Human Hair Atlas is publicly accessible (https://metabolomics.cloud/hair/), providing a resource to stimulate research in hair metabolomics, lipidomics, and exposomics, and to explore the potential of hair as a complementary matrix in clinical studies.