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<p>Kcnq channels are low-threshold voltage-dependent K<sup>+</sup> channels that generate M-currents, which regulate the peri-threshold membrane potential. Kcnq channels reportedly participate in band-pass frequency responses (i.e., resonance), but it remains largely unclear how they contribute to generating resonance. We examined resonance in HEK293 cells expressing <i>mouse Kcnq2</i> and <i>Kcnq3</i> (<i>Kcnq2/3</i>) using whole-cell recording. <i>Kcnq2/3</i>-expressing cells generated resonance-like frequency-dependent responses. Kcnh7 channels displayed a rapid opposing conductance change followed by slow activation in response to a depolarizing voltage step, properties thought to be necessary for inductor-like activity. However, Kcnq2/3 channels exhibited only slow activation. The lack of an opposing conductance change was caused by the absence of rapid Kcnq2/3 channel inactivation. These data suggest that core ion channel characteristics that cause resonance-like frequency responses are not uniform among ion channels. The opposing conductance change is not necessary for resonance-like frequency responses but is crucial for fine frequency tuning and oscillation.</p>

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Kcnq (Kv7) channels exhibit frequency-dependent responses via partial inductor-like gating dynamics

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月5日

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  • Yuta Eguchi,
  • Yuki Kuwano,
  • Satoshi Okada,
  • Hiroyuki Morino,
  • Kouichi Hashimoto

摘要

Kcnq channels are low-threshold voltage-dependent K+ channels that generate M-currents, which regulate the peri-threshold membrane potential. Kcnq channels reportedly participate in band-pass frequency responses (i.e., resonance), but it remains largely unclear how they contribute to generating resonance. We examined resonance in HEK293 cells expressing mouse Kcnq2 and Kcnq3 (Kcnq2/3) using whole-cell recording. Kcnq2/3-expressing cells generated resonance-like frequency-dependent responses. Kcnh7 channels displayed a rapid opposing conductance change followed by slow activation in response to a depolarizing voltage step, properties thought to be necessary for inductor-like activity. However, Kcnq2/3 channels exhibited only slow activation. The lack of an opposing conductance change was caused by the absence of rapid Kcnq2/3 channel inactivation. These data suggest that core ion channel characteristics that cause resonance-like frequency responses are not uniform among ion channels. The opposing conductance change is not necessary for resonance-like frequency responses but is crucial for fine frequency tuning and oscillation.