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<p><i>Plasmodium vivax</i> malaria is a major public health problem outside sub-Saharan Africa. However, an increasing number of <i>P. vivax</i> infections in Duffy-negative individuals has been reported across Africa in recent years, raising concerns that the parasites may have evolved alternative pathways to invade reticulocyte and overcome Duffy-negativity. Here, we investigated the global genetic structure and diversity of sub-Saharan African <i>P. vivax</i> populations, exploring possible molecular signatures of adaptation to Duffy-negative hosts. We analyzed 204 previously published <i>P. vivax</i> genome sequences from Africa, Southeast Asia, the Pacific Coral Triangle, and South America and generated whole-genome sequences of 133 <i>P. vivax</i> field isolates collected from 10 sub-Saharan African countries. Our analysis revealed four distinct geographic clusters, with clear contrasts between East/West Africa and the Indian Ocean populations. Despite the limited number of interpretable sequences from Duffy-negative individuals - attributable to low parasitemia - and the lack of clear evidence of selective pressure acting on invasion-related genes of the <i>P. vivax</i> parasite populations circulating in sub-Saharan Africa, our study offers valuable insights into the genetic diversity of <i>P. vivax</i> and lays the groundwork for future research exploring parasite adaptation to Duffy-negative hosts.</p>

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Genomic analysis of Plasmodium vivax field isolates circulating in sub-Saharan Africa

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月7日

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  • Isabelle Bouyssou,
  • Lemu Golassa,
  • Inès Vigan-Womas,
  • Matthieu Schoenhals,
  • Arsène Ratsimbasoa,
  • Ali Ould Mohamed Salem Boukhary,
  • Maria de Fátima Ferreira-da-Cruz,
  • Sandrine Houzé,
  • Laurence Ma,
  • Feng Lu,
  • Chetan Chitnis,
  • Pascal Campagne,
  • Didier Ménard

摘要

Plasmodium vivax malaria is a major public health problem outside sub-Saharan Africa. However, an increasing number of P. vivax infections in Duffy-negative individuals has been reported across Africa in recent years, raising concerns that the parasites may have evolved alternative pathways to invade reticulocyte and overcome Duffy-negativity. Here, we investigated the global genetic structure and diversity of sub-Saharan African P. vivax populations, exploring possible molecular signatures of adaptation to Duffy-negative hosts. We analyzed 204 previously published P. vivax genome sequences from Africa, Southeast Asia, the Pacific Coral Triangle, and South America and generated whole-genome sequences of 133 P. vivax field isolates collected from 10 sub-Saharan African countries. Our analysis revealed four distinct geographic clusters, with clear contrasts between East/West Africa and the Indian Ocean populations. Despite the limited number of interpretable sequences from Duffy-negative individuals - attributable to low parasitemia - and the lack of clear evidence of selective pressure acting on invasion-related genes of the P. vivax parasite populations circulating in sub-Saharan Africa, our study offers valuable insights into the genetic diversity of P. vivax and lays the groundwork for future research exploring parasite adaptation to Duffy-negative hosts.