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<p>The composition of the infant gut microbiome is critical to immune development and noncommunicable disease (NCD) trajectory. However, a comprehensive evaluation of the infant gut microbiome in the United States is lacking. The My Baby Biome study, designed to address this knowledge gap, evaluated the gut microbiomes of 412 infants (representative of U.S. demographic diversity) using metagenomics and metabolomics. Regardless of birth mode and/or feeding method, widespread <i>Bifidobacterium</i> deficit was observed, with approximately 25% of U.S. infants lacking detectable <i>Bifidobacterium</i>. <i>Bifidobacterium</i>-dominant microbiomes exhibit distinct features when compared to microbiomes with other dominant microbial compositions including reduced antimicrobial resistance and virulence factor genes, altered carbohydrate utilization pathways, and altered metabolic signatures. In C-section birth infants, <i>Bifidobacterium</i> tended to be replaced in the human milk oligosaccharide utilization niche with potentially pathogenic species. Longitudinal health outcomes from these infants suggest that the disappearance of key <i>Bifidobacterium</i> may contribute to the development of atopy.</p><p></p>

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Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月24日

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  • John B. Jarman,
  • Pedro J. Torres,
  • Sean Stromberg,
  • Hirokazu Sato,
  • Caroline Stack,
  • Angelica Ladrillono,
  • Shannon Pace,
  • Natalia Livier Jimenez,
  • Robert J. Haselbeck,
  • Richard Insel,
  • Stephen Van Dien,
  • Stephanie J. Culler

摘要

The composition of the infant gut microbiome is critical to immune development and noncommunicable disease (NCD) trajectory. However, a comprehensive evaluation of the infant gut microbiome in the United States is lacking. The My Baby Biome study, designed to address this knowledge gap, evaluated the gut microbiomes of 412 infants (representative of U.S. demographic diversity) using metagenomics and metabolomics. Regardless of birth mode and/or feeding method, widespread Bifidobacterium deficit was observed, with approximately 25% of U.S. infants lacking detectable Bifidobacterium. Bifidobacterium-dominant microbiomes exhibit distinct features when compared to microbiomes with other dominant microbial compositions including reduced antimicrobial resistance and virulence factor genes, altered carbohydrate utilization pathways, and altered metabolic signatures. In C-section birth infants, Bifidobacterium tended to be replaced in the human milk oligosaccharide utilization niche with potentially pathogenic species. Longitudinal health outcomes from these infants suggest that the disappearance of key Bifidobacterium may contribute to the development of atopy.