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<p>Schizophrenia is a neurodevelopmental condition with alterations in both sensory and association cortical areas. These alterations have been reported to follow structural connectivity patterning, and to occur in a system-level fashion. Here we investigated whether pathological alterations of schizophrenia originate from an early disruption of cortical organization. We found a structural covariance gradient axis of cortical thickness discriminated anterior from posterior region and was compressed in early-onset schizophrenia (EOS) patients. Patients showed increased structural covariance between two ends of the anterior-posterior axis, with increased geodesic distance of covarying regions between two ends. Positive symptoms increased with the strengthening of structural covariance between two ends. Our findings revealed a contracted organizational axis in EOS patients, which was attributed to excessive distally coordinated changes between anterior and posterior cortical regions. Our study from a systematic perspective suggests disturbed maturational processes of cortical thickness in EOS, supporting the neurodevelopmental hypothesis of schizophrenia.</p>

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Anterior-posterior systematic deficits of cortical thickness in early-onset schizophrenia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月21日

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  • Yun-Shuang Fan,
  • Yong Xu,
  • Bin Wan,
  • Wei Sheng,
  • Chong Wang,
  • Mi Yang,
  • Sofie Louise Valk,
  • Huafu Chen

摘要

Schizophrenia is a neurodevelopmental condition with alterations in both sensory and association cortical areas. These alterations have been reported to follow structural connectivity patterning, and to occur in a system-level fashion. Here we investigated whether pathological alterations of schizophrenia originate from an early disruption of cortical organization. We found a structural covariance gradient axis of cortical thickness discriminated anterior from posterior region and was compressed in early-onset schizophrenia (EOS) patients. Patients showed increased structural covariance between two ends of the anterior-posterior axis, with increased geodesic distance of covarying regions between two ends. Positive symptoms increased with the strengthening of structural covariance between two ends. Our findings revealed a contracted organizational axis in EOS patients, which was attributed to excessive distally coordinated changes between anterior and posterior cortical regions. Our study from a systematic perspective suggests disturbed maturational processes of cortical thickness in EOS, supporting the neurodevelopmental hypothesis of schizophrenia.