Scholarlink

<p>The secondary motor cortex (M2) plays an important role in the adaptive control of locomotor behaviors. However, it is unclear how M2 neurons encode the same type of locomotor control variables in different environmental contexts. Here we image the neuronal activity in M2 with a miniscope while mice are moving freely in each of three environments: a Y-maze, a running-wheel, and an open-field. These animals show distinct locomotor patterns in different environmental contexts. Surprisingly, a large population of M2 neurons are active before starting and after ceasing locomotion, while maintaining decreased neural activity during locomotion. Furthermore, the majority of these neurons are consistently engaged across various contexts, suggesting egocentric voluntary control functions. In contrast, the smaller populations of locomotion-activated M2 neurons are mostly context-specific, suggesting exocentric navigation functions. Thus, our results demonstrate that M2 neurons encode motor control variables for self-initiated locomotor behaviors in both context-dependent and context-independent manners.</p><p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Neural representation of self-initiated locomotion in the secondary motor cortex of mice across different environmental contexts

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月10日

查看全文
  • Guanglong Sun,
  • Chencen Yu,
  • Ruolan Cai,
  • Mingxuan Li,
  • Lingzhu Fan,
  • Hao Sun,
  • Chenfei Lyu,
  • Yingxu Lin,
  • Lixia Gao,
  • Kuan Hong Wang,
  • Xinjian Li

摘要

The secondary motor cortex (M2) plays an important role in the adaptive control of locomotor behaviors. However, it is unclear how M2 neurons encode the same type of locomotor control variables in different environmental contexts. Here we image the neuronal activity in M2 with a miniscope while mice are moving freely in each of three environments: a Y-maze, a running-wheel, and an open-field. These animals show distinct locomotor patterns in different environmental contexts. Surprisingly, a large population of M2 neurons are active before starting and after ceasing locomotion, while maintaining decreased neural activity during locomotion. Furthermore, the majority of these neurons are consistently engaged across various contexts, suggesting egocentric voluntary control functions. In contrast, the smaller populations of locomotion-activated M2 neurons are mostly context-specific, suggesting exocentric navigation functions. Thus, our results demonstrate that M2 neurons encode motor control variables for self-initiated locomotor behaviors in both context-dependent and context-independent manners.