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<p>Tracheal regeneration remains a major challenge due to the lack of efficient graft integration and functional restoration. Current approaches fail to address oxidative stress-induced tissue remodeling. Here, we show that the glutathione pathway plays a pivotal role in tracheal regeneration with aortic allografts by modulating redox homeostasis and promoting host-graft integration. Through transcriptomic profiling, histological analyses, and functional assessment, we demonstrate that antioxidant-driven tissue remodeling enhances epithelialization, neovascularization, and extracellular matrix organization, thereby improving graft stability and biomechanical properties. These findings provide mechanistic insights into oxidative stress-mediated tissue remodeling and suggest that targeting redox signaling could optimize bioengineered tracheal grafts for clinical translation.</p>

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The role of the glutathione pathway in tracheal regeneration with aortic allografts through antioxidant-driven tissue integration

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月28日

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  • Shixiong Wei,
  • Yao Zhi,
  • Zhou Chen,
  • Yiyuan Zhang,
  • Kexing Duan,
  • Mingqian Li,
  • Guoyue Lv

摘要

Tracheal regeneration remains a major challenge due to the lack of efficient graft integration and functional restoration. Current approaches fail to address oxidative stress-induced tissue remodeling. Here, we show that the glutathione pathway plays a pivotal role in tracheal regeneration with aortic allografts by modulating redox homeostasis and promoting host-graft integration. Through transcriptomic profiling, histological analyses, and functional assessment, we demonstrate that antioxidant-driven tissue remodeling enhances epithelialization, neovascularization, and extracellular matrix organization, thereby improving graft stability and biomechanical properties. These findings provide mechanistic insights into oxidative stress-mediated tissue remodeling and suggest that targeting redox signaling could optimize bioengineered tracheal grafts for clinical translation.