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<p>Adult <i>Schistosoma</i> produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling schistosomiasis. Here, we describe that <i>Bantam</i> miRNA and <i>miR-1989</i> regulate Wnt signaling pathway by targeting <i>Frizzled-5/7/9</i>, which is involved in ovarian development and oviposition. Additionally, Frizzled-7 could cooperate with SjRho to maintain normal ovarian development and egg productions and SjRho may interact with Hsp60 to potentially support Frizzled-7 trafficking and signaling. Further in vivo inhibition of <i>SjRho</i> in mice model infected with <i>Schistosoma</i> results in a remarkable decrease in worm burden and egg productions. Our findings not only broaden the functions of <i>Bantam</i> miRNA and <i>miR-1989</i> as well as Wnt signaling pathway, but also imply that interruption of <i>Bantam</i>/<i>miR-1989</i>-Frizzled-5/7/9-SjRho axis may serve as effective targets against schistosomiasis.</p>

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Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2024年12月31日

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  • Pengfei Du,
  • Tianqi Xia,
  • Xuxin Li,
  • Bikash R. Giri,
  • Chuantao Fang,
  • Shun Li,
  • Shi Yan,
  • Guofeng Cheng

摘要

Adult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling schistosomiasis. Here, we describe that Bantam miRNA and miR-1989 regulate Wnt signaling pathway by targeting Frizzled-5/7/9, which is involved in ovarian development and oviposition. Additionally, Frizzled-7 could cooperate with SjRho to maintain normal ovarian development and egg productions and SjRho may interact with Hsp60 to potentially support Frizzled-7 trafficking and signaling. Further in vivo inhibition of SjRho in mice model infected with Schistosoma results in a remarkable decrease in worm burden and egg productions. Our findings not only broaden the functions of Bantam miRNA and miR-1989 as well as Wnt signaling pathway, but also imply that interruption of Bantam/miR-1989-Frizzled-5/7/9-SjRho axis may serve as effective targets against schistosomiasis.