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Genome-wide association studies for pelvic organ prolapse in the Japanese population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2024年9月30日

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  • Masatoshi Matsunami,
  • Minako Imamura,
  • Asuka Ashikari,
  • Xiaoxi Liu,
  • Kohei Tomizuka,
  • Keiko Hikino,
  • Kosei Miwa,
  • Katsumi Kadekawa,
  • Tetsuji Suda,
  • Takayuki Morisaki,
  • Yukinori Okada,
  • Yoichiro Kamatani,
  • Kaori Muto,
  • Akiko Nagai,
  • Yoji Sagiya,
  • Natsuhiko Kumasaka,
  • Yoichi Furukawa,
  • Yuji Yamanashi,
  • Yoshinori Murakami,
  • Yusuke Nakamura,
  • Wataru Obara,
  • Ken Yamaji,
  • Kazuhisa Takahash,
  • Satoshi Asai,
  • Yasuo Takahashi,
  • Shinichi Higashiue,
  • Shuzo Kobayashi,
  • Hiroki Yamaguchi,
  • Yasunobu Nagata,
  • Satoshi Wakita,
  • Chikako Nito,
  • Yu-ki Iwasaki,
  • Shigeo Murayama,
  • Kozo Yoshimori,
  • Yoshio Miki,
  • Daisuke Obata,
  • Masahiko Higashiyama,
  • Akihide Masumoto,
  • Yoshinobu Koga,
  • Yukihiro Koretsune,
  • Koichi Matsuda,
  • Minoru Miyazato,
  • Chikashi Terao,
  • Shiro Maeda

摘要

Pelvic organ prolapse (POP) affects approximately 40% of elderly women, characterized by the descent of the pelvic organs into the vaginal cavity. Here we present the results of a genome-wide association study (GWAS) for susceptibility to POP comprising 771 cases and 76,625 controls in the Japanese population. We identified a significant association of WT1 locus with POP in the Japanese population; rs10742277; odds ratio (OR) = 1.48, 95% confidence interval (CI), 1.29–1.68, P = 6.72 × 10−9. Subsequent cross-ancestry GWAS meta-analysis combining the Japanese data and previously reported European data, including 28,857 cases and 622,916 controls, identified FGFR2 locus as a novel susceptibility locus to POP (rs7072877; OR = 1.06, 95% CI, 1.04–1.08, P = 4.11 × 10−8). We also observed consistent directions of the effects for 21 out of 24 European GWAS derived loci (binomial test P = 2.8 × 10−4), indicating that most of susceptibility loci for POP are shared across the Japanese and European populations.