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Ventrointermediate thalamic stimulation improves motor learning in humans

  • Angela Voegtle,
  • Laila Terzic,
  • Amr Farahat,
  • Nanna Hartong,
  • Imke Galazky,
  • Hermann Hinrichs,
  • Slawomir J. Nasuto,
  • Adriano de Oliveira Andrade,
  • Robert T. Knight,
  • Richard B. Ivry,
  • Jürgen Voges,
  • Matthias Deliano,
  • Lars Buentjen,
  • Catherine M. Sweeney-Reed

摘要

Ventrointermediate thalamic stimulation (VIM-DBS) modulates oscillatory activity in a cortical network including primary motor cortex, premotor cortex, and parietal cortex. Here we show that, beyond the beneficial effects of VIM-DBS on motor execution, this form of invasive stimulation facilitates production of sequential finger movements that follow a repeated sequence. These results highlight the role of thalamo–cortical activity in motor learning.