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<p>Wireless bioresorbable systems for electrical stimulation can deliver electrotherapy over clinically relevant timeframes, and then subsequently dissolve away in a harmless fashion. Such systems have previously been used in neuroregeneration and cardiac pacing, delivering monophasic pulses to a targeted site. Here we report a wirelessly powered system with programmable control of the stimulation waveforms using tissue-penetrating near-infrared light. The approach relies on a bioresorbable silicon phototransistor that is designed to optically modulate current flows at critical nodes in electrical circuits. We show that the approach can offer precise control over stimulation pulses—allowing monophasic, biphasic and polyphasic waveforms to be delivered to single or multiple sites—and all with power wirelessly delivered to a single receiver unit. Using small and large animal models, we further show that the technology enables single- and dual-chamber cardiac pacing, as well as phrenic neuromuscular stimulation for inducing and blocking diaphragmatic excursion.</p>

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A wirelessly powered, light-controlled, bioresorbable stimulation system with programmable polyphasic waveforms

  • 期刊论文

  • 发表日期：

    2026年6月16日

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  • Jong Uk Kim,
  • Seung Gi Seo,
  • Hongkai Wang,
  • Eric Rytkin,
  • Jiarui Gong,
  • Jie Zhou,
  • Junhwan Choi,
  • Jiwon Kim,
  • Sun Young Park,
  • Anna Pfenniger,
  • Rishi K. Arora,
  • Aleksei Mikhailov,
  • Jinheon Jeong,
  • Seungyeob Kim,
  • Yamin Zhang,
  • Ravi F. Nuxoll,
  • Hak-Young Ahn,
  • Geumbee Lee,
  • Shupeng Li,
  • Dae-Hyeon Song,
  • Sangwon Cha,
  • Young Jin Jo,
  • Sang Min Won,
  • Tae-il Kim,
  • Yei Hwan Jung,
  • Sumanas W. Jordan,
  • Yonggang Huang,
  • Jae-Young Yoo,
  • Igor R. Efimov,
  • Colin K. Franz,
  • Zhenqiang Ma,
  • Sung Hun Jin,
  • John A. Rogers

摘要

Wireless bioresorbable systems for electrical stimulation can deliver electrotherapy over clinically relevant timeframes, and then subsequently dissolve away in a harmless fashion. Such systems have previously been used in neuroregeneration and cardiac pacing, delivering monophasic pulses to a targeted site. Here we report a wirelessly powered system with programmable control of the stimulation waveforms using tissue-penetrating near-infrared light. The approach relies on a bioresorbable silicon phototransistor that is designed to optically modulate current flows at critical nodes in electrical circuits. We show that the approach can offer precise control over stimulation pulses—allowing monophasic, biphasic and polyphasic waveforms to be delivered to single or multiple sites—and all with power wirelessly delivered to a single receiver unit. Using small and large animal models, we further show that the technology enables single- and dual-chamber cardiac pacing, as well as phrenic neuromuscular stimulation for inducing and blocking diaphragmatic excursion.