Accelerated intestinal wound healing via dual electrostimulation from a soft and biodegradable electronic bandage
摘要
Intestinal wound healing is a long-standing problem, with conventional suturing-based intestinal closure surgeries typically leading to postoperative problems. Alternative strategies or devices capable of effective wound healing have thus been sought. Here we report a self-powered electronic bandage made from soft and biodegradable materials that can accelerate wound healing in the intestine. The device uses dual electrostimulation to promote wound healing: a pulsed electrostimulation that induces electrotransfection of epithelial cells, promoting the expression of healing factors (such as epithelial growth factor); and a d.c. electrostimulation that enhances secretion of healing factors of the transfected cells. The electronic bandage exhibits high transfection efficiency and cell viability for intestinal epithelial cells in vitro, which boosts epithelial growth factor expression during the intraoperative period. Its self-powered galvanic cell from a magnesium and molybdenum microelectrode pair promotes healing factor exocytosis. In vitro and in vivo studies in mice show accelerated intestinal would healing compared to conventional suture-based treatments and an electronic bandage with single electrostimulation.