<p>The human respiratory system can remove most pollutants from inhaled air through the abundance of mucus and cilia on curved airway surfaces. Inspired by such a gas–liquid interface, here we develop an electrostatic open-microfluidics (EOM) system for biomimetic air purification. The EOM system features electrostatic field-assisted polarization and deflection and dynamically refreshed gas–liquid interface of open-microfluidics. Due to the surface energy difference and tailored wettability, particulate pollutants in the air are preferentially captured at the gas–liquid interface, enhanced by extra electric field force. Besides, polarized gaseous pollutants can be activated by free radicals and electrons and removed by customized functional liquids. Additionally, herringbone-like open channels contribute to sufficient interaction between flowing air and liquids, further updating the interface and improving the removal efficiency. The application potential of the EOM system is demonstrated for air purification in domestic scenarios and lung disease prevention. Moreover, the operability and integration capabilities endow the EOM system with application potential for scaled-up industrial exhaust gas purification. Overall, this work provides a viable approach for efficient air purification.</p>