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<p>Plant-based materials provide a renewable and sustainable platform for tackling global challenges in energy, environment and healthcare. Among these, chronic diabetic wounds, currently affecting over 10% of the global population, remain a pressing public health crisis, largely owing to persistent hypoxia and unresolved inflammation. Here we report photosynthetic microspheres derived from the invasive aquatic plant <i>Eichhornia crassipes</i> (water hyacinth) as a green therapeutic strategy for chronic wound repair. Harnessing intact chloroplasts, these biogenic microspheres deliver sustained oxygen evolution for up to 3 weeks, alleviating local hypoxia and restoring redox balance. When integrated with the metabolic regulator metformin, the system couples exogenous photosynthesis and endogenous glucose metabolism, synergistically reprogramming the wound microenvironment. In both mouse and pig diabetic wound models, this approach suppresses inflammation, promotes angiogenesis and expedites re-epithelialization, leading to adaptive tissue regeneration. Our findings reveal that inexpensive, invasive aquatic biomass can be upcycled into advanced therapeutic biomaterials, offering a scalable and sustainable framework for next-generation regenerative medicine.</p>

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Upcycling plant biomass into photosynthetic microspheres for diabetic wound healing

  • 期刊论文

  • 发表日期：

    2026年5月1日

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  • Jiayi Ding,
  • Yuna Qian,
  • Hailin Xie,
  • Rui Zhao,
  • Linwei Huang,
  • Minjiang Chen,
  • Hongtao Xu,
  • Jiansong Ji,
  • Jianliang Shen

摘要

Plant-based materials provide a renewable and sustainable platform for tackling global challenges in energy, environment and healthcare. Among these, chronic diabetic wounds, currently affecting over 10% of the global population, remain a pressing public health crisis, largely owing to persistent hypoxia and unresolved inflammation. Here we report photosynthetic microspheres derived from the invasive aquatic plant Eichhornia crassipes (water hyacinth) as a green therapeutic strategy for chronic wound repair. Harnessing intact chloroplasts, these biogenic microspheres deliver sustained oxygen evolution for up to 3 weeks, alleviating local hypoxia and restoring redox balance. When integrated with the metabolic regulator metformin, the system couples exogenous photosynthesis and endogenous glucose metabolism, synergistically reprogramming the wound microenvironment. In both mouse and pig diabetic wound models, this approach suppresses inflammation, promotes angiogenesis and expedites re-epithelialization, leading to adaptive tissue regeneration. Our findings reveal that inexpensive, invasive aquatic biomass can be upcycled into advanced therapeutic biomaterials, offering a scalable and sustainable framework for next-generation regenerative medicine.