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<p>Lengthy acquisition time remains a key bottleneck for the widespread use of MRI in clinics. While accelerated MRI can reduce scan duration, it often introduces increased noise, compromising image quality and diagnostic reliability. In this study, we present a unified deep learning-based denoising model for multi-organ accelerated MRI, designed to operate directly on reconstructed images from commercial MRI systems. Our model was trained on a prospectively collected, large-scale real-world dataset comprising 148,930 noisy-clean image pairs from six clinical centers and four major MRI vendors, spanning six organs and 96 MRI protocols. On a test set of 20,143 real-world image pairs, our model consistently outperforms state-of-the-art denoising methods. Importantly, downstream evaluation using tissue segmentation demonstrates a 7.05% improvement in Dice score across multiple organs compared to noisy images. The model further generalizes effectively to 46,870 external clinical images from four independent cohorts, highlighting its robustness across various scanners and acquisition protocols. To assess clinical utility, two experienced radiologists conducted blinded evaluations across multiple organs, focusing on overall image quality, diagnostic confidence, and disease diagnosis. The denoised images retained high visual fidelity and yielded diagnostic performance equivalent to clean images even with acceleration factor of 3× compared to clinical scanning setup, such that many acquisitions can be completed within one minute. This unified MRI denoising model holds great potential for various clinical applications.</p>

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Real-world unified denoising for multi-organ fast MRI: a large-scale prospective validation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月19日

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  • Yuchen Shao,
  • Hongyan Huang,
  • Lingyan Zhang,
  • Dongsheng Li,
  • Zhiguang Ding,
  • Fan Wang,
  • Shengli Chen,
  • Shiwei Lin,
  • Yuning Gu,
  • Mu Du,
  • Hongbing Li,
  • Jiuping Liang,
  • Xiaoqian Huang,
  • Aowen Liu,
  • Jiafu Zhong,
  • Yiqiang Zhan,
  • Xiang Sean Zhou,
  • Feng Shi,
  • Shu Liao,
  • Kaicong Sun,
  • Dinggang Shen,
  • Yingwei Qiu

摘要

Lengthy acquisition time remains a key bottleneck for the widespread use of MRI in clinics. While accelerated MRI can reduce scan duration, it often introduces increased noise, compromising image quality and diagnostic reliability. In this study, we present a unified deep learning-based denoising model for multi-organ accelerated MRI, designed to operate directly on reconstructed images from commercial MRI systems. Our model was trained on a prospectively collected, large-scale real-world dataset comprising 148,930 noisy-clean image pairs from six clinical centers and four major MRI vendors, spanning six organs and 96 MRI protocols. On a test set of 20,143 real-world image pairs, our model consistently outperforms state-of-the-art denoising methods. Importantly, downstream evaluation using tissue segmentation demonstrates a 7.05% improvement in Dice score across multiple organs compared to noisy images. The model further generalizes effectively to 46,870 external clinical images from four independent cohorts, highlighting its robustness across various scanners and acquisition protocols. To assess clinical utility, two experienced radiologists conducted blinded evaluations across multiple organs, focusing on overall image quality, diagnostic confidence, and disease diagnosis. The denoised images retained high visual fidelity and yielded diagnostic performance equivalent to clean images even with acceleration factor of 3× compared to clinical scanning setup, such that many acquisitions can be completed within one minute. This unified MRI denoising model holds great potential for various clinical applications.