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<p>App-based cognitive behavioral therapy (app-CBT) addresses many treatment barriers. We randomized 120 U.S. adults with primary OCD (82.4% female, 77.5% White, mean age 40.1) between 7/2021 and 7/2023 to 12-weeks of coach-guided Perspectives (<i>n</i> = 60; app-CBT) or coach-guided HealthWatch (<i>n</i> = 60; an online well-being program). OCD severity (Yale-Brown Obsessive Compulsive Scale; primary outcome) analyzed using a pre-registered mixed linear model showed a trend level group difference at post-treatment (ES = −0.47; <i>p</i> = 0.079). However, results from secondary and sensitivity analyses showed significantly better outcomes in Perspectives after adjusting for baseline differences or varying missing data assumptions (<i>p</i>s &lt; 0.05). Response rates among completers were 65% in Perspectives and 41% in HealthWatch. Perspectives was also associated with greater pre-to-post-treatment improvement in functioning (ES = −0.55; <i>p</i> = 0.014). 83% of completers in Perspectives were mostly/very satisfied and 91% recommended the program vs. 43% and 53% in HealthWatch. Results highlight app-CBT as an effective and feasible treatment option for OCD that addresses dissemination obstacles.Clinicaltrials.gov identifier: <a href="https://clinicaltrials.gov/study/NCT04136626">NCT04136626</a> (Registration Date: 10/17/2019).</p>

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A randomized clinical trial of app cognitive behavior therapy vs. HealthWatch for obsessive compulsive disorder

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月15日

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  • Sabine Wilhelm,
  • Jennifer L. Greenberg,
  • Ryan J. Jacoby,
  • Hilary Weingarden,
  • Susanne S. Hoeppner,
  • Dalton Klare,
  • Ivar Snorrason,
  • Adam C. Jaroszewski,
  • Thomas H. McCoy,
  • Oliver Harrison

摘要

App-based cognitive behavioral therapy (app-CBT) addresses many treatment barriers. We randomized 120 U.S. adults with primary OCD (82.4% female, 77.5% White, mean age 40.1) between 7/2021 and 7/2023 to 12-weeks of coach-guided Perspectives (n = 60; app-CBT) or coach-guided HealthWatch (n = 60; an online well-being program). OCD severity (Yale-Brown Obsessive Compulsive Scale; primary outcome) analyzed using a pre-registered mixed linear model showed a trend level group difference at post-treatment (ES = −0.47; p = 0.079). However, results from secondary and sensitivity analyses showed significantly better outcomes in Perspectives after adjusting for baseline differences or varying missing data assumptions (ps < 0.05). Response rates among completers were 65% in Perspectives and 41% in HealthWatch. Perspectives was also associated with greater pre-to-post-treatment improvement in functioning (ES = −0.55; p = 0.014). 83% of completers in Perspectives were mostly/very satisfied and 91% recommended the program vs. 43% and 53% in HealthWatch. Results highlight app-CBT as an effective and feasible treatment option for OCD that addresses dissemination obstacles.Clinicaltrials.gov identifier: NCT04136626 (Registration Date: 10/17/2019).