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<p>Effective first-trimester screening for congenital heart disease (CHD) remains an unmet clinical need, hampered by technical limitations and the absence of validated diagnostic tools. To address this, we collected a vast cohort of 108,521 first-trimester cardiac screenings conducted across multiple regions in China, from which 8062 Doppler flow four-chamber view images were selected. Using this curated dataset, we developed and validated an interpretable deep learning (DL) model that mimics clinical reasoning with diastolic flow patterns, providing accurate and explainable CHD diagnosis in first-trimester. Interpretability analyses confirmed its diagnostic logic strongly aligns with clinical expertise. In rigorous evaluations, the model demonstrated high accuracy across multiple external validation datasets, matched or surpassed experienced clinicians, and showed potential to augment their diagnostic capabilities. To our knowledge, this is the first validated interpretable DL system for first-trimester CHD screening, potentially enabling earlier intervention through an advanced diagnostic window.</p>

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An interpretable deep learning model for first-trimester fetal cardiac screening

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月8日

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  • Wenjia Lei,
  • Chi Wen,
  • He Li,
  • Shuihua Yang,
  • Kuifang Shen,
  • Hongxia Yuan,
  • Hezhou Li,
  • Hong Xu,
  • Xinru Gao,
  • Simin Zhang,
  • Zuojian Yang,
  • Mang Ye,
  • Bo Du,
  • Qingqing Wu

摘要

Effective first-trimester screening for congenital heart disease (CHD) remains an unmet clinical need, hampered by technical limitations and the absence of validated diagnostic tools. To address this, we collected a vast cohort of 108,521 first-trimester cardiac screenings conducted across multiple regions in China, from which 8062 Doppler flow four-chamber view images were selected. Using this curated dataset, we developed and validated an interpretable deep learning (DL) model that mimics clinical reasoning with diastolic flow patterns, providing accurate and explainable CHD diagnosis in first-trimester. Interpretability analyses confirmed its diagnostic logic strongly aligns with clinical expertise. In rigorous evaluations, the model demonstrated high accuracy across multiple external validation datasets, matched or surpassed experienced clinicians, and showed potential to augment their diagnostic capabilities. To our knowledge, this is the first validated interpretable DL system for first-trimester CHD screening, potentially enabling earlier intervention through an advanced diagnostic window.