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<p>Preventing mental disorders is important to avoiding clinical conditions. This study evaluated the efficacy of internet-based indicated prevention for anxiety and depressive disorders. In a three-arm randomized controlled trial, 566 adults with subthreshold anxiety (GAD-7 ≥ 5) and/or depressive symptoms (CES-D ≥ 16), but no clinical diagnosis in the past six months (MINI 6.0), were assigned to either an individually (IG-IMI, <i>n</i> = 186) or automatically (AG-IMI, <i>n</i> = 189) guided digital intervention, or waitlist control (WLC, <i>n</i> = 191). The digital intervention comprised 8 transdiagnostic, self-tailored, CBT-based sessions. The primary outcome was time to onset of any anxiety or depressive disorder over 12 months, assessed via blinded diagnostic interviews (MINI). AD/DD onset was 19.4% in IG-IMI, 14.8% in AG-IMI, and 30.9% in WLC. Cumulative incidence was 23.1% (IG-IMI), 20.7% (AG-IMI), and 36.0% (WLC; <i>p</i> &lt; 0.001). Hazard ratios were 0.59 and 0.47; NNTs were 7.76 and 5.79. Both individually guided and automated interventions effectively reduced AD/DD incidence. <b>Trial Registration:</b> The study was preregistered in the German Clinical Trial Registration (DRKS00011099; <a href="https://drks.de/search/de/trial/DRKS00011099">https://drks.de/search/de/trial/DRKS00011099</a>).</p>

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Internet-based indicated prevention of anxiety and depression disorder onset three-arm randomized clinical trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月1日

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  • Anna-Carlotta Zarski,
  • Kiona K. Weisel,
  • Thomas Berger,
  • Tobias Krieger,
  • Michael P. Schaub,
  • Matthias Berking,
  • Dennis Görlich,
  • Corinna Jacobi,
  • Rosa Baños,
  • Cristina Botella,
  • Rocio Herrero,
  • David D. Ebert

摘要

Preventing mental disorders is important to avoiding clinical conditions. This study evaluated the efficacy of internet-based indicated prevention for anxiety and depressive disorders. In a three-arm randomized controlled trial, 566 adults with subthreshold anxiety (GAD-7 ≥ 5) and/or depressive symptoms (CES-D ≥ 16), but no clinical diagnosis in the past six months (MINI 6.0), were assigned to either an individually (IG-IMI, n = 186) or automatically (AG-IMI, n = 189) guided digital intervention, or waitlist control (WLC, n = 191). The digital intervention comprised 8 transdiagnostic, self-tailored, CBT-based sessions. The primary outcome was time to onset of any anxiety or depressive disorder over 12 months, assessed via blinded diagnostic interviews (MINI). AD/DD onset was 19.4% in IG-IMI, 14.8% in AG-IMI, and 30.9% in WLC. Cumulative incidence was 23.1% (IG-IMI), 20.7% (AG-IMI), and 36.0% (WLC; p < 0.001). Hazard ratios were 0.59 and 0.47; NNTs were 7.76 and 5.79. Both individually guided and automated interventions effectively reduced AD/DD incidence. Trial Registration: The study was preregistered in the German Clinical Trial Registration (DRKS00011099; https://drks.de/search/de/trial/DRKS00011099).