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<p>Depressive symptoms pose a serious global threat to well-being, highlighting the need for scalable mental health interventions. E-mental health interventions offer promising population-level solutions, yet few are grounded in theory or tested on large samples. This study utilizes an innovative e-mental health intervention based on the Extended Process Model of Emotion Regulation and examines the effectiveness of this theory-based intervention across a randomized controlled trial (RCT, <i>N</i> = 187; Chinese Clinical Trial Registry: ChiCTR2400081964; registration date: March 18th, 2024) and two extensive real-world studies (<i>N</i><sub>study 2</sub> = 11,554, <i>N</i><sub>study 3</sub> = 44,018) conducted with adults in China. The RCT confirmed the efficacy of this intervention, and both of the real-world e-mental health intervention studies showed a decrease in depressive symptoms (35–36%) and an increase in well-being (14–16%) over 21 days. These findings highlight the potential of theory-based e-mental health interventions as scalable solutions for early depression intervention and prevention, offering substantial societal and economic advantages.</p>

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A scalable mental health intervention for depressive symptoms: evidence from a randomized controlled trial and large-scale real-world studies

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月1日

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  • Jianjie Xu,
  • Zhuo Rachel Han,
  • Xiangxi Lv,
  • Lu Chen,
  • Ningning Mao,
  • Mengyu Miranda Gao,
  • Hanyi Zhang,
  • Yueqin Hu,
  • Shaozheng Qin,
  • James J. Gross,
  • Zhanjun Zhang

摘要

Depressive symptoms pose a serious global threat to well-being, highlighting the need for scalable mental health interventions. E-mental health interventions offer promising population-level solutions, yet few are grounded in theory or tested on large samples. This study utilizes an innovative e-mental health intervention based on the Extended Process Model of Emotion Regulation and examines the effectiveness of this theory-based intervention across a randomized controlled trial (RCT, N = 187; Chinese Clinical Trial Registry: ChiCTR2400081964; registration date: March 18th, 2024) and two extensive real-world studies (Nstudy 2 = 11,554, Nstudy 3 = 44,018) conducted with adults in China. The RCT confirmed the efficacy of this intervention, and both of the real-world e-mental health intervention studies showed a decrease in depressive symptoms (35–36%) and an increase in well-being (14–16%) over 21 days. These findings highlight the potential of theory-based e-mental health interventions as scalable solutions for early depression intervention and prevention, offering substantial societal and economic advantages.