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<p>The assessment of corneal fluorescein staining is essential, yet current AI models for Corneal Staining Score (CSS) assessments inadequately identify punctate lesions due to annotation challenges and noise, risk misrepresenting treatment responses through “plateau” effects, and highlight the necessity for real-world evaluations to enhance disease severity assessments. To address these limitations, we developed the Fine-grained Knowledge Distillation Corneal Staining Score (FKD-CSS) model. FKD-CSS integrates fine-grained features into CSS grading, providing continuous and nuanced scores with interpretability. Trained on corneal staining images collected from dry eye (DE) patients across 14 hospitals, FKD-CSS achieved robust accuracy, with a Pearson’s r of 0.898 and an AUC of 0.881 in internal validation, matching senior ophthalmologists’ performance. External tests on 2376 images from 23 hospitals across China further validated its efficacy (r: 0.844–0.899, AUC: 0.804-0.883). Additionally, FKD-CSS demonstrated generalizability in multi-ocular-surface-disease testing, underscoring its potential in handling different staining patterns.</p>

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Advanced and interpretable corneal staining assessment through fine grained knowledge distillation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月23日

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  • Yuqing Deng,
  • Pujin Cheng,
  • Ruiwen Xu,
  • Lirong Ling,
  • Hongliang Xue,
  • Shiyou Zhou,
  • Yansong Huang,
  • Junyan Lyu,
  • Zhonghua Wang,
  • Kenneth K. Y. Wong,
  • Yimin Zhang,
  • Kang Yu,
  • Tingting Zhang,
  • Xiaoqing Hu,
  • Xiaoyi Li,
  • Xiaoying Tang,
  • Yan Lou,
  • Jin Yuan

摘要

The assessment of corneal fluorescein staining is essential, yet current AI models for Corneal Staining Score (CSS) assessments inadequately identify punctate lesions due to annotation challenges and noise, risk misrepresenting treatment responses through “plateau” effects, and highlight the necessity for real-world evaluations to enhance disease severity assessments. To address these limitations, we developed the Fine-grained Knowledge Distillation Corneal Staining Score (FKD-CSS) model. FKD-CSS integrates fine-grained features into CSS grading, providing continuous and nuanced scores with interpretability. Trained on corneal staining images collected from dry eye (DE) patients across 14 hospitals, FKD-CSS achieved robust accuracy, with a Pearson’s r of 0.898 and an AUC of 0.881 in internal validation, matching senior ophthalmologists’ performance. External tests on 2376 images from 23 hospitals across China further validated its efficacy (r: 0.844–0.899, AUC: 0.804-0.883). Additionally, FKD-CSS demonstrated generalizability in multi-ocular-surface-disease testing, underscoring its potential in handling different staining patterns.