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<p>Therapeutic cancer vaccines activate tumor-specific T-cells to reduce tumor burden, yet face challenges when integrating and translating multi-level complex preclinical data into actionable insights. We present a model-based framework to integrate diverse preclinical data, comparing synthetic long peptide vaccines with or without adjuvant stimuli to a vaccine-drug conjugate approach by Adaptable Drug Affinity Conjugate technology. This technology provides modular and rapid conjugate formation via high-affinity binding between a peptide-tagged vaccine antigen and a CD40-targeting antibody, acting as an adjuvant and delivery vehicle. Our developed semi-mechanistic modelling framework successfully linked dosing to tumor dynamics, incorporating four sub-models: pharmacokinetic, peptide uptake by antigen-presenting cells, T-cell response, and tumor growth in TC-1 and MC38 tumors. Model-based simulations highlighted the importance of affinity conjugation on pharmacokinetics and efficacy. Effector T-cells mediated tumor shrinkage. Antibody dose-dependent effects were identified and quantified in the immune-responsive MC38 model. This framework supports rational vaccine optimization and translational decision-making. The graphical abstract was created in <a href="https://BioRender.com">https://BioRender.com</a>.</p><p></p>

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Evaluating neoantigen-vaccine responses through mechanistic and model-based frameworks

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月24日

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  • Eman I. K. Ibrahim,
  • Ida Laurén,
  • Rosanne E. Veerman,
  • Siv Jönsson,
  • A. Jimmy Ytterberg,
  • Annika Lindqvist,
  • Sara M. Mangsbo,
  • Lena E. Friberg

摘要

Therapeutic cancer vaccines activate tumor-specific T-cells to reduce tumor burden, yet face challenges when integrating and translating multi-level complex preclinical data into actionable insights. We present a model-based framework to integrate diverse preclinical data, comparing synthetic long peptide vaccines with or without adjuvant stimuli to a vaccine-drug conjugate approach by Adaptable Drug Affinity Conjugate technology. This technology provides modular and rapid conjugate formation via high-affinity binding between a peptide-tagged vaccine antigen and a CD40-targeting antibody, acting as an adjuvant and delivery vehicle. Our developed semi-mechanistic modelling framework successfully linked dosing to tumor dynamics, incorporating four sub-models: pharmacokinetic, peptide uptake by antigen-presenting cells, T-cell response, and tumor growth in TC-1 and MC38 tumors. Model-based simulations highlighted the importance of affinity conjugation on pharmacokinetics and efficacy. Effector T-cells mediated tumor shrinkage. Antibody dose-dependent effects were identified and quantified in the immune-responsive MC38 model. This framework supports rational vaccine optimization and translational decision-making. The graphical abstract was created in https://BioRender.com.