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<p>Thymic epithelial tumors (TETs) are rare and diverse cancers with distinctive immune features, limited prospective evidence, and few systemic options. Their association with autoimmunity, especially thymomas, complicates treatment decisions. This review examines molecular profiling and predictive biomarkers in TET and explores new treatment strategies. We highlight priorities for future trials, global registries, and real-world data to expand access to expert, multidisciplinary care, charting a path toward precision-guided, combination-based treatments.</p>

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Redefining therapeutic horizons in thymic epithelial tumors: precision, combinations, and emerging biology

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月26日

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  • Jennifer A. Marks,
  • Rohan Maniar,
  • Kavitha J. Ramchandran,
  • Erica Pietroluongo,
  • Mehmet Altan,
  • Surbhi Singhal,
  • Mihaela Aldea,
  • Jonathan W. Goldman,
  • Jonathan W. Reiss,
  • Heather Wakelee,
  • Patrick J. Loehrer,
  • Marina Chiara Garassino,
  • Anja C. Roden,
  • Jordi Remon,
  • Christopher S. Nabel,
  • Chul Kim

摘要

Thymic epithelial tumors (TETs) are rare and diverse cancers with distinctive immune features, limited prospective evidence, and few systemic options. Their association with autoimmunity, especially thymomas, complicates treatment decisions. This review examines molecular profiling and predictive biomarkers in TET and explores new treatment strategies. We highlight priorities for future trials, global registries, and real-world data to expand access to expert, multidisciplinary care, charting a path toward precision-guided, combination-based treatments.