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<p>Sexual hormone receptors (SHRs) are essential for breast cancer (BCa) pathogenesis. BCa is a prevalent malignancy with high heterogeneity and high recurrence. Endocrine resistance remains a major clinical challenge. SHR-mediated transcription involves complex epigenetic, post-translational, and inter-receptor crosstalk, and dysregulation of these processes contributes to endocrine resistance. This review aims to summarize the current progress on the molecular mechanism underlying the function of nucleic SHRs in BCa, providing insights for the novel therapeutic strategies in BCa.</p>

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Nucleic sexual hormone receptor signaling pathways in breast cancer: function regulation, crosstalk, and therapeutic implications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月22日

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  • Kai Zeng,
  • Anqi Wang,
  • Hongmiao Sun,
  • Chunyu Wang,
  • Shengli Wang,
  • Renlong Zou,
  • Dongjun Yang,
  • Yu Bai,
  • Manlin Wang,
  • Yingying Xu,
  • Yue Zhao

摘要

Sexual hormone receptors (SHRs) are essential for breast cancer (BCa) pathogenesis. BCa is a prevalent malignancy with high heterogeneity and high recurrence. Endocrine resistance remains a major clinical challenge. SHR-mediated transcription involves complex epigenetic, post-translational, and inter-receptor crosstalk, and dysregulation of these processes contributes to endocrine resistance. This review aims to summarize the current progress on the molecular mechanism underlying the function of nucleic SHRs in BCa, providing insights for the novel therapeutic strategies in BCa.