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<p>Personalized treatment in head and neck cancer remains limited despite substantial biological heterogeneity. Using the SuPerTreat project as a case study, we outline a prototype clinical decision support system (CDSS) integrating transcriptomic data and artificial intelligence (AI), and summarize expert consensus on its potential, requirements for accuracy, validation, regulatory alignment, and clinical implementation. This Perspective provides a roadmap to guide future development and responsible integration of CDSS into precision oncology.</p>

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Integrating transcriptomic data and artificial intelligence to personalize curative treatments for head and neck cancer patients

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月14日

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  • Stefano Cavalieri,
  • Loris De Cecco,
  • Dario Monzani,
  • Hisham Mehanna,
  • Renata Ferrarotto,
  • Christian Simon,
  • Robert Haddad,
  • Pierre Saintigny,
  • Christophe Le Tourneau,
  • Lisa Licitra

摘要

Personalized treatment in head and neck cancer remains limited despite substantial biological heterogeneity. Using the SuPerTreat project as a case study, we outline a prototype clinical decision support system (CDSS) integrating transcriptomic data and artificial intelligence (AI), and summarize expert consensus on its potential, requirements for accuracy, validation, regulatory alignment, and clinical implementation. This Perspective provides a roadmap to guide future development and responsible integration of CDSS into precision oncology.