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<p>Squamous transformation of prostate adenocarcinoma is a rare resistance mechanism in patients with advanced prostate cancer that impacts both prognosis and treatment. Herein, we profile circulating chromatin in serial plasma samples collected from a patient with metastatic prostate cancer that experienced squamous transformation. We detect dynamic changes in gene regulation from circulating chromatin reflecting the emergence of squamous differentiation, enabling non-invasive diagnosis and monitoring of this resistance phenotype, with potential therapeutic implications.</p>

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Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月9日

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  • Karl Semaan,
  • Rashad Nawfal,
  • John Canniff,
  • Hunter Savignano,
  • Ji-Heui Seo,
  • Stephanie E. Siegmund,
  • Sarah J. Wu,
  • Julia K. Rotow,
  • Gwo-Shu Mary Lee,
  • Razane El Hajj Chehade,
  • Ze Zhang,
  • Gunsagar S. Gulati,
  • Noa Phillips,
  • Garyoung Gary Lee,
  • Christopher A. French,
  • Michelle S. Hirsch,
  • Heather A. Jacene,
  • Atish D. Choudhury,
  • Toni K. Choueiri,
  • Matthew L. Freedman,
  • Sylvan C. Baca,
  • Jacob E. Berchuck

摘要

Squamous transformation of prostate adenocarcinoma is a rare resistance mechanism in patients with advanced prostate cancer that impacts both prognosis and treatment. Herein, we profile circulating chromatin in serial plasma samples collected from a patient with metastatic prostate cancer that experienced squamous transformation. We detect dynamic changes in gene regulation from circulating chromatin reflecting the emergence of squamous differentiation, enabling non-invasive diagnosis and monitoring of this resistance phenotype, with potential therapeutic implications.