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<p><i>CIC</i>::<i>DUX4</i> translocation-positive sarcomas (CDS) are rare, highly proliferative tumors associated with chemotherapy resistance. Without a clear understanding of the molecular pathways driving CDS, no effective treatment regimens have been developed. Here, we identify protection against DNA damage through upregulation of <i>POLE</i> and DNA repair pathways specific to CDS. These data may explain the high proliferation rate and chemotherapy resistance of these tumors and suggest targeted treatment strategies for CDS.</p>

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Upregulation of POLE and proficient DNA repair are features of CIC::DUX4 sarcomas

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月20日

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  • Nathan D. Seligson,
  • Anjali Paragji,
  • Feha Shahalam,
  • Binyam Yilma,
  • James L. Chen

摘要

CIC::DUX4 translocation-positive sarcomas (CDS) are rare, highly proliferative tumors associated with chemotherapy resistance. Without a clear understanding of the molecular pathways driving CDS, no effective treatment regimens have been developed. Here, we identify protection against DNA damage through upregulation of POLE and DNA repair pathways specific to CDS. These data may explain the high proliferation rate and chemotherapy resistance of these tumors and suggest targeted treatment strategies for CDS.