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<p>Brain metastases (BM) occur frequently in lung cancer, particularly in non-small cell lung cancer (NSCLC) patients and remain a significant cause of morbidity and mortality. Standard therapies have limited efficacy due to poor crossing of the blood-brain barrier and the distinct features between BM and the primary tumor. This review explores the immune landscape of brain metastatic disease, emerging immunotherapeutic strategies, and promising biomarkers in NSCLC patients.</p>

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Immunotherapy in lung cancer brain metastases

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月6日

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  • Eunice Paisana,
  • Rita Cascão,
  • Magda Alvoeiro,
  • Francisco Félix,
  • Guilherme Martins,
  • Carla Guerreiro,
  • Rafael Roque,
  • Rafael Cruz,
  • Teresa R. Pacheco,
  • Ana Cristina Amado,
  • Filipa Ferro,
  • Andrea Lopes Machado,
  • Ana Sofia Vilariça,
  • Direndra Hasmucrai,
  • Paula Alves,
  • Claudia C. Faria

摘要

Brain metastases (BM) occur frequently in lung cancer, particularly in non-small cell lung cancer (NSCLC) patients and remain a significant cause of morbidity and mortality. Standard therapies have limited efficacy due to poor crossing of the blood-brain barrier and the distinct features between BM and the primary tumor. This review explores the immune landscape of brain metastatic disease, emerging immunotherapeutic strategies, and promising biomarkers in NSCLC patients.