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<p>High-grade serous ovarian cancer (HGSOC) presents challenges in prognostic prediction. This study aimed to develop a universal foundation model-driven multimodal model (FoMu model) to assess the prognosis of HGSOC patients. We conducted a retrospective cohort study involving 712 eligible patients across four centers, collecting clinical, MRI, and hematoxylin and eosin (H&amp;E)-stained whole slide images (WSIs) data. Pre-trained radiological and pathological foundation models were employed for feature precoding. Subsequently, we introduced unimodal and cross-modal adaptive aggregation networks to comprehensively model the features derived from each modality. Our findings revealed that both unimodal and cross-modal FoMu models exhibited superior and stable predictive capabilities for overall survival (OS) and progression-free survival (PFS). In summary, our study successfully developed a FoMu model that effectively integrates multimodal data to assess the prognoses of HGSOC patients, highlighting its potential for improving individualized patient management and clinical decision-making in future applications.</p>

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Foundation model-driven multimodal prognostic prediction in patients undergoing primary surgery for high-grade serous ovarian cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月20日

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  • Qiu Bi,
  • Conghui Ai,
  • Linhao Qu,
  • Qingyin Meng,
  • Qinqing Wang,
  • Jing Yang,
  • Ao Zhou,
  • Wenwei Shi,
  • Ying Lei,
  • Yunzhu Wu,
  • Yang Liu,
  • Haiming Li,
  • Jinwei Qiang

摘要

High-grade serous ovarian cancer (HGSOC) presents challenges in prognostic prediction. This study aimed to develop a universal foundation model-driven multimodal model (FoMu model) to assess the prognosis of HGSOC patients. We conducted a retrospective cohort study involving 712 eligible patients across four centers, collecting clinical, MRI, and hematoxylin and eosin (H&E)-stained whole slide images (WSIs) data. Pre-trained radiological and pathological foundation models were employed for feature precoding. Subsequently, we introduced unimodal and cross-modal adaptive aggregation networks to comprehensively model the features derived from each modality. Our findings revealed that both unimodal and cross-modal FoMu models exhibited superior and stable predictive capabilities for overall survival (OS) and progression-free survival (PFS). In summary, our study successfully developed a FoMu model that effectively integrates multimodal data to assess the prognoses of HGSOC patients, highlighting its potential for improving individualized patient management and clinical decision-making in future applications.