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<p>Here, we review a growing paradigm shift from genomics-based precision medicine toward <i>functional</i> precision medicine, which evaluates therapeutic efficacy by directly treating living patient tumors ex vivo to better predict patient-specific responses to treatment. We discuss several classes of patient-derived models of central nervous system tumors, highlighting unique features of each. Each class of models holds promise to improve treatment selection, prolong survival, and enhance patient outcomes.</p>

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Opportunities and challenges for patient-derived models of brain tumors in functional precision medicine

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月14日

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  • Breanna Mann,
  • Nichole Artz,
  • Rami Darawsheh,
  • David E. Kram,
  • Shawn Hingtgen,
  • Andrew B. Satterlee

摘要

Here, we review a growing paradigm shift from genomics-based precision medicine toward functional precision medicine, which evaluates therapeutic efficacy by directly treating living patient tumors ex vivo to better predict patient-specific responses to treatment. We discuss several classes of patient-derived models of central nervous system tumors, highlighting unique features of each. Each class of models holds promise to improve treatment selection, prolong survival, and enhance patient outcomes.