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<p>Mammals have evolved under an inseparable association with diverse microbial gut colonizers; thus, fine-tuned host−microbial interactions shape our susceptibility to immunological, oncogenic, metabolic and infectious outcomes. The past two decades have seen a rapid expansion of research into intestinal bacterial communities that impact host health in many preclinical and clinical settings. Meanwhile, other less abundant microorganism domains, including fungi, remain far less explored. This Review provides an overview of the literature on the gut mycobiome and evidence of its contributions to host physiology and disease over the past two decades in experimental rodent models, which have been foundational to our current understanding of host−microbe interactions.</p>

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The role of the mycobiome in host physiology and disease: insights from rodent models

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月14日

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  • Karen Antunes,
  • Nathaniel B. Willis,
  • Joseph F. Pierre

摘要

Mammals have evolved under an inseparable association with diverse microbial gut colonizers; thus, fine-tuned host−microbial interactions shape our susceptibility to immunological, oncogenic, metabolic and infectious outcomes. The past two decades have seen a rapid expansion of research into intestinal bacterial communities that impact host health in many preclinical and clinical settings. Meanwhile, other less abundant microorganism domains, including fungi, remain far less explored. This Review provides an overview of the literature on the gut mycobiome and evidence of its contributions to host physiology and disease over the past two decades in experimental rodent models, which have been foundational to our current understanding of host−microbe interactions.