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<p>Air displacement plethysmography (ADP) estimates of fat mass (FM) and lean mass (LM) usually assume constant LM density, which may reduce accuracy in children with obesity. We aimed to validate FM and LM from ADP by adjusting LM density according to the degree of obesity at the one-year follow-up, and to assess their ability to track longitudinal changes. This prospective study included 37 children with obesity aged 9–14 years. Body composition was assessed before and after a 12-month intervention using four-component (4&#xa0;C) model. FM and LM (Kg) from ADP assuming constant LM density (FM<sub>D−k</sub> and LM<sub>D−k</sub>) were compared with those from adjusted LM densities (LM<sub>D−adj</sub> and FM<sub>D−adj</sub>), and both compared to 4&#xa0;C model. Cross-sectionally, ADP-adjusted model did not differ from 4&#xa0;C model, whereas constant-density ADP did (<i>p</i> &lt; 0.001). Bland–Altman plots showed better agreement with 4&#xa0;C model for the adjusted method (FM<sub>D−adj</sub> -0.51 (-2.48, 1.46) vs. FM<sub>D−k</sub> -1.47 (-3.69, 0.75)). In longitudinal analysis, Bland-Altman plots indicated that the two ADP methods were highly consistent with those from the 4&#xa0;C model (FM<sub>D−adj</sub> 0.24 (-2.02, 2.50) vs. FM<sub>D−k</sub> 0.07 (-2.25, 2.39)). Adjusting LM density according to obesity improves cross-sectional accuracy of ADP estimates, while longitudinal tracking performance remains similar between methods.</p>

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Longitudinal validation of equations for predicting fat and lean mass from air displacement plethysmography in children with obesity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月5日

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  • Judit Muñoz-Hernando,
  • Emma Perucho,
  • Mireia Alcázar,
  • Mariona Gispert-Llauradó,
  • Natalia Ferré,
  • Joaquín Escribano,
  • Verónica Luque

摘要

Air displacement plethysmography (ADP) estimates of fat mass (FM) and lean mass (LM) usually assume constant LM density, which may reduce accuracy in children with obesity. We aimed to validate FM and LM from ADP by adjusting LM density according to the degree of obesity at the one-year follow-up, and to assess their ability to track longitudinal changes. This prospective study included 37 children with obesity aged 9–14 years. Body composition was assessed before and after a 12-month intervention using four-component (4 C) model. FM and LM (Kg) from ADP assuming constant LM density (FMD−k and LMD−k) were compared with those from adjusted LM densities (LMD−adj and FMD−adj), and both compared to 4 C model. Cross-sectionally, ADP-adjusted model did not differ from 4 C model, whereas constant-density ADP did (p < 0.001). Bland–Altman plots showed better agreement with 4 C model for the adjusted method (FMD−adj -0.51 (-2.48, 1.46) vs. FMD−k -1.47 (-3.69, 0.75)). In longitudinal analysis, Bland-Altman plots indicated that the two ADP methods were highly consistent with those from the 4 C model (FMD−adj 0.24 (-2.02, 2.50) vs. FMD−k 0.07 (-2.25, 2.39)). Adjusting LM density according to obesity improves cross-sectional accuracy of ADP estimates, while longitudinal tracking performance remains similar between methods.