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<p>Conventional wound treatments often fail due to their restricted efficacy. The discovery of multitargeted medication represents a crucial step in turning scientific discoveries into clinically possible solutions. The development of polymer-based multicomponent-loaded nanofibrous scaffolds as an innovative platform for wound healing applications is the important objective of the current work. For topical wound healing applications, sulfonated polyether ether ketone (SPEEK) serves as carrier that contains analgesics such as paracetamol, diclofenac sodium, and methanolic extract of <i>Strobilanthes ciliata</i>. The mat’s surface, thermal, structural and chemical properties were measured using various characterization techniques, like SEM, TGA, FT-IR, and contact angle measurements, respectively. SEM results of the nanofibers showed an average diameter between 100 and 160&#xa0;nm, and FT-IR spectroscopy confirmed the presence of major functional groups, indicating the presence of the loaded components. Contact angle measurements (39º to 90º) indicated suitable hydrophilicity for wound exudate absorption, and the thermogravimetric analysis showed an excellent thermal stability. Water uptake studies showed the swelling ability of the mats for up to 24&#xa0;h. <i>In vitro</i> drug release studies demonstrated a suitable drug release profile for 12 days, which followed zero-order kinetics and was driven by a diffusion-based mechanism. Furthermore, the mats exhibited favourable hemocompatibility with less than 10% hemolysis. A scratch assay was performed, which exhibited 74% wound healing capability.</p>

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A preliminary evaluation of SPEEK nanofibers as multi-drug carrier delivering diclofenac, paracetamol and alcoholic extract of Strobilanthes ciliata

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月5日

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  • Shreya Balamurugan,
  • Aswathi Malampallaparambil,
  • Himabindu Padinjarathil,
  • Prasanna Ramani

摘要

Conventional wound treatments often fail due to their restricted efficacy. The discovery of multitargeted medication represents a crucial step in turning scientific discoveries into clinically possible solutions. The development of polymer-based multicomponent-loaded nanofibrous scaffolds as an innovative platform for wound healing applications is the important objective of the current work. For topical wound healing applications, sulfonated polyether ether ketone (SPEEK) serves as carrier that contains analgesics such as paracetamol, diclofenac sodium, and methanolic extract of Strobilanthes ciliata. The mat’s surface, thermal, structural and chemical properties were measured using various characterization techniques, like SEM, TGA, FT-IR, and contact angle measurements, respectively. SEM results of the nanofibers showed an average diameter between 100 and 160 nm, and FT-IR spectroscopy confirmed the presence of major functional groups, indicating the presence of the loaded components. Contact angle measurements (39º to 90º) indicated suitable hydrophilicity for wound exudate absorption, and the thermogravimetric analysis showed an excellent thermal stability. Water uptake studies showed the swelling ability of the mats for up to 24 h. In vitro drug release studies demonstrated a suitable drug release profile for 12 days, which followed zero-order kinetics and was driven by a diffusion-based mechanism. Furthermore, the mats exhibited favourable hemocompatibility with less than 10% hemolysis. A scratch assay was performed, which exhibited 74% wound healing capability.