<p>In pharmaceutical formulations, the description or prediction of the final drug form (i.e. tablet) performance remains challenging when relying solely on material or process input parameters. Tablet microstructure analysis offers a beneficial alternative, particularly when solid dispersions are in the formulation. They provide a way to enhance drug bioavailability via partial or full amorphisation of the active substance (API) and stabilisation of the amorphous form. Moreover, they can have specific particulate properties that favour tablet performance description via microstructure (deformability due to higher amounts of polymer - especially in hot-melt extrudates). The purpose of this work was to apply an image-based method for tablet microstructure description to model systems containing solid dispersions. Two binary systems containing solid dispersion of API prepared via hot-melt extrusion and CaHPO₄∙2H₂O were tested. One, containing API rivaroxaban, varying extrudate properties (particle size, plasticiser content) with fixed tablet composition, the second with fixed extrudate properties and variable composition containing API indomethacin. When tablet composition remained constant, extrudate characteristics dominated tablet performance description over tablet microstructure and porosity. With fixed extrudate properties, the application of the image-based microstructure evaluation method proved to be sensible and provided further insight into its application. For the tested combination of indomethacin-Kollidon VA64 extrudate with excipient CaHPO₄∙2H₂O, the best description of dissolution properties was achieved using the <i>d</i>(10) values (excipient observable areas on tablet cross-sections). The obtained results extend the previously proposed microstructure-based approach for describing dissolution performance to solid-dispersion-based tablets, providing a more specialised possible model system.</p>