Scholarlink

<p>Implantable collamer lens (ICLs) surgery is increasingly used for myopia correction, yet postoperative narrowing of the iridocorneal angle (IA) has been associated with elevated intraocular pressure (IOP). Prior computational studies treated IA geometry and trabecular meshwork (TM) microstructure independently, leaving unresolved how IA narrowing alters TM pore structure and outflow resistance. Here, we combined optical coherence tomography with multi-scale computational fluid dynamics, coupling a macroscopic anterior-segment model with a TM representative volume element (RVE) to quantify the IA–porosity–IOP relationship. Modifying IA geometry alone produced negligible IOP changes (0.02–0.04 Pa posterior-chamber elevation), even at the narrowest angle of 16.6°. RVE simulations showed that angle-related TM deformation reduced porosity from 0.39 to 0.20. This porosity loss increased the mean pressure gradient by more than 1.5-fold and induced channelized flow near an RVE-derived transition porosity of 0.27. Larger IAs enhanced natural convection, increasing peak aqueous humour velocity by approximately 472%, while wall shear stress remained below endothelial detachment thresholds. These results identify TM pore deformation as a mechanical mechanism linking IA narrowing to increased aqueous outflow resistance and IOP. This mechanistic framework may guide precision ocular interventions, though patient-specific anatomical variability and time-dependent effects remain to be incorporated.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of iridocorneal angle on aqueous humor flow after implantable collamer lens placement by numerical simulation analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月28日

查看全文
  • Liangqi Zheng,
  • Zhiyong Huang,
  • Jing Tang,
  • Yingping Deng

摘要

Implantable collamer lens (ICLs) surgery is increasingly used for myopia correction, yet postoperative narrowing of the iridocorneal angle (IA) has been associated with elevated intraocular pressure (IOP). Prior computational studies treated IA geometry and trabecular meshwork (TM) microstructure independently, leaving unresolved how IA narrowing alters TM pore structure and outflow resistance. Here, we combined optical coherence tomography with multi-scale computational fluid dynamics, coupling a macroscopic anterior-segment model with a TM representative volume element (RVE) to quantify the IA–porosity–IOP relationship. Modifying IA geometry alone produced negligible IOP changes (0.02–0.04 Pa posterior-chamber elevation), even at the narrowest angle of 16.6°. RVE simulations showed that angle-related TM deformation reduced porosity from 0.39 to 0.20. This porosity loss increased the mean pressure gradient by more than 1.5-fold and induced channelized flow near an RVE-derived transition porosity of 0.27. Larger IAs enhanced natural convection, increasing peak aqueous humour velocity by approximately 472%, while wall shear stress remained below endothelial detachment thresholds. These results identify TM pore deformation as a mechanical mechanism linking IA narrowing to increased aqueous outflow resistance and IOP. This mechanistic framework may guide precision ocular interventions, though patient-specific anatomical variability and time-dependent effects remain to be incorporated.