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<p>Heatstroke is a life-threatening systemic disorder characterized by hyperthermia, inflammatory activation, endothelial injury, and multiple organ dysfunction. The liver is particularly vulnerable, but effective post-onset therapeutic strategies remain limited. This study examined whether intravenous hydrogen-rich acetated Ringer’s solution (H-AR) attenuates liver injury after heatstroke onset in rats, in comparison with acetated Ringer’s solution alone (Control) and 2% hydrogen inhalation (HI). Liver injury was assessed 60&#xa0;min after onset using histological scoring and liver enzyme measurements. Circulating markers of inflammation and endothelial injury, endothelial glycocalyx ultrastructure, and 24-h survival were also evaluated. Thermal exposure was comparable among the heatstroke groups. Both H-AR and HI significantly reduced histological liver injury scores compared with Control; H-AR showed significantly greater attenuation than HI and was the only intervention that significantly reduced alanine aminotransferase levels. Both hydrogen-based interventions suppressed high-mobility group box 1 and syndecan-1, preserved endothelial glycocalyx structure, and improved 24-h survival compared with Control. These findings suggest that post-onset intravenous H-AR attenuates heatstroke-associated liver injury, potentially through reduced inflammatory activation and endothelial glycocalyx preservation, and may offer advantages over hydrogen inhalation with respect to hepatoprotection.</p>

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Intravenous hydrogen-rich acetated Ringer’s solution attenuates liver injury in heatstroke rats through endothelial glycocalyx preservation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月25日

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  • Ryo Ayata,
  • Motoki Fujita,
  • Yasutaka Oda,
  • Kayoko Harada,
  • Kodai Suzuki,
  • Yasutaka Koga,
  • Masaki Todani,
  • Ryosuke Tsuruta

摘要

Heatstroke is a life-threatening systemic disorder characterized by hyperthermia, inflammatory activation, endothelial injury, and multiple organ dysfunction. The liver is particularly vulnerable, but effective post-onset therapeutic strategies remain limited. This study examined whether intravenous hydrogen-rich acetated Ringer’s solution (H-AR) attenuates liver injury after heatstroke onset in rats, in comparison with acetated Ringer’s solution alone (Control) and 2% hydrogen inhalation (HI). Liver injury was assessed 60 min after onset using histological scoring and liver enzyme measurements. Circulating markers of inflammation and endothelial injury, endothelial glycocalyx ultrastructure, and 24-h survival were also evaluated. Thermal exposure was comparable among the heatstroke groups. Both H-AR and HI significantly reduced histological liver injury scores compared with Control; H-AR showed significantly greater attenuation than HI and was the only intervention that significantly reduced alanine aminotransferase levels. Both hydrogen-based interventions suppressed high-mobility group box 1 and syndecan-1, preserved endothelial glycocalyx structure, and improved 24-h survival compared with Control. These findings suggest that post-onset intravenous H-AR attenuates heatstroke-associated liver injury, potentially through reduced inflammatory activation and endothelial glycocalyx preservation, and may offer advantages over hydrogen inhalation with respect to hepatoprotection.