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<p>Optical coherence tomography (OCT) enables high-resolution imaging in compact fiber-optic configurations, making it attractive for minimally invasive applications. We present a non-rotational, multi-channel endoscopic OCT (E-OCT) catheter capable of trajectory-resolved imaging without mechanical scanning. The device integrates four ultrathin side-viewing fiber probes within a biopsy-compatible housing and employs time-division multiplexing for sequential multi-angle acquisition. This architecture provides structural, vascular, and flow contrast from spatially separated regions while maintaining mechanical stability. The system was validated using tissue-mimicking phantoms, ex vivo glioma-bearing rat brains, and an in vivo rabbit glioma model. Experimental results demonstrated consistent multi-slice endoscopic imaging and reliable visualization of tissue microstructure and vascular features from tumor-associated and adjacent non-tumor regions. These proof-of-concept findings from the single in vivo study indicate the feasibility of using multimodal E-OCT imaging to provide complementary structural and vascular information during stereotactic brain biopsy.</p>

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Non-rotational multi-channel endoscopic OCT for trajectory-resolved imaging in stereotactic brain biopsy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月4日

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  • Woo June Choi,
  • Junyoung Hwang,
  • Chanho Kong,
  • Sangheon Han,
  • Jiwon Baek,
  • Junhyung Kim,
  • Won Seok Chang,
  • Sucbei Moon

摘要

Optical coherence tomography (OCT) enables high-resolution imaging in compact fiber-optic configurations, making it attractive for minimally invasive applications. We present a non-rotational, multi-channel endoscopic OCT (E-OCT) catheter capable of trajectory-resolved imaging without mechanical scanning. The device integrates four ultrathin side-viewing fiber probes within a biopsy-compatible housing and employs time-division multiplexing for sequential multi-angle acquisition. This architecture provides structural, vascular, and flow contrast from spatially separated regions while maintaining mechanical stability. The system was validated using tissue-mimicking phantoms, ex vivo glioma-bearing rat brains, and an in vivo rabbit glioma model. Experimental results demonstrated consistent multi-slice endoscopic imaging and reliable visualization of tissue microstructure and vascular features from tumor-associated and adjacent non-tumor regions. These proof-of-concept findings from the single in vivo study indicate the feasibility of using multimodal E-OCT imaging to provide complementary structural and vascular information during stereotactic brain biopsy.