Scholarlink

Background <p>The prognostic value of Cockcroft-Gault estimated creatinine clearance (CG-CrCl) in critically ill cerebrovascular disease (CVD) patients is unclear.</p> Methods <p>This retrospective cohort study included 8,732 adults from MIMIC-IV. CG-CrCl was examined continuously and by quartiles. Primary outcome was 30-day mortality; secondary outcomes were 90-day and 365-day mortality. Multivariable Cox models, restricted cubic splines, and two-piecewise linear regression assessed associations.</p> Results <p>Overall 30-day, 90-day, and 365-day mortality rates were 17.6%, 22.2%, and 28.8%, respectively. In fully adjusted models, each 1-standard deviation (SD; 45.46 mL/min) decrease in CG-CrCl was independently associated with increased mortality risk (30-day: HR 1.35, 95% CI 1.25–1.45; 90-day: HR 1.32, 95% CI 1.24–1.41; 365-day: HR 1.31, 95% CI 1.24–1.39). A significant nonlinear threshold effect was identified: the association became pronounced only below inflection points of 119.66, 114.84, and 114.89 mL/min for 30-, 90-, and 365-day mortality, respectively. Adding CG-CrCl did not significantly improve discrimination at any time point (all DeLong <i>P</i> &gt; 0.05).</p> Conclusion <p>CG-CrCl is independently associated with short- and long-term mortality in critically ill CVD patients with a nonlinear threshold effect, suggesting it may serve as a readily available risk marker worthy of further validation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Nonlinear association between cockcroft-gault creatinine clearance and all-cause mortality in critically ill cerebrovascular disease patients: a retrospective cohort study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月17日

查看全文
  • Hui Wang

摘要

Background

The prognostic value of Cockcroft-Gault estimated creatinine clearance (CG-CrCl) in critically ill cerebrovascular disease (CVD) patients is unclear.

Methods

This retrospective cohort study included 8,732 adults from MIMIC-IV. CG-CrCl was examined continuously and by quartiles. Primary outcome was 30-day mortality; secondary outcomes were 90-day and 365-day mortality. Multivariable Cox models, restricted cubic splines, and two-piecewise linear regression assessed associations.

Results

Overall 30-day, 90-day, and 365-day mortality rates were 17.6%, 22.2%, and 28.8%, respectively. In fully adjusted models, each 1-standard deviation (SD; 45.46 mL/min) decrease in CG-CrCl was independently associated with increased mortality risk (30-day: HR 1.35, 95% CI 1.25–1.45; 90-day: HR 1.32, 95% CI 1.24–1.41; 365-day: HR 1.31, 95% CI 1.24–1.39). A significant nonlinear threshold effect was identified: the association became pronounced only below inflection points of 119.66, 114.84, and 114.89 mL/min for 30-, 90-, and 365-day mortality, respectively. Adding CG-CrCl did not significantly improve discrimination at any time point (all DeLong P > 0.05).

Conclusion

CG-CrCl is independently associated with short- and long-term mortality in critically ill CVD patients with a nonlinear threshold effect, suggesting it may serve as a readily available risk marker worthy of further validation.