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<p>The aim of this study was to investigate the antifungal effects of the combination of carvacrol and biosynthesized CuO nanoparticles (NPs) with the aqueous extract of Satureja khuzestanica plant against <i>Candida albicans</i> and <i>Candida tropicalis</i> fungi. Four different modes were used to investigate the effect of fungi inactivation, aqueous extract of Satureja khuzestanica plant alone, synthesizing CuO NPs green, Carvacrol 98%, and composition of green CuO NPs and carvacrol 98%. To reduce environmental degradation effects, a simple and green approach for preparation and synthesis of nanoparticles was used. Different concentration of substances produced was applied to investigate the antifungal effects on fungal pathogens namely <i>Candida albicans</i> and <i>Candida tropicalis</i>. In this study, time-kill curve assay were determined for the experiments. Also, the studied concentrations were 1/2MIC, Minimum Inhibitory Concentration, MIC, 2MIC, 4MIC, and 8MIC. According to the obtained results, CuO NPs were spherical in shape and almost uniform in size, with an average diameter of 70&#xa0;nm. The lowest concentration of MIC and Minimum Fungi Concentration (MFC) was observed in combined disinfectants Carvacrol 98%+CuO NPs. The results of analysis of variance (ANOVA) showed that there is a significant difference in the disinfecting and disinfecting power of compounds Carvacrol 98% and Carvacrol 98%+CuO NPs (P<sub>value</sub>&lt;005). In this combination, <i>Candida tropicalis</i>, the concentration of MIC and MFC was equal to 31 ± 25 and 52.08 ± 18.04&#xa0;µg/mL, respectively. Satureja khuzestanica + CuO NPs and Carvacrol 98% was strength in <i>Candida tropicalis</i> in all the investigated concentrations, e.g. MIC, 2MIC, and 4MIC.</p>

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Green synthesis of copper nanoparticles using Satureja khuzestanica plant and investigation of its antifungal properties: Candida albicans and Candida tropicalis, an in vitro study

  • 期刊论文

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  • 发表日期：

    2026年7月9日

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  • Razie Naghdi Talaee,
  • Mansour Ghaderpoori,
  • Mohsen Mohammadi,
  • Mohammad Yarahmadi,
  • Bahram Kamarehie,
  • Faramrz Azimi,
  • Fatemeh Arbabi

摘要

The aim of this study was to investigate the antifungal effects of the combination of carvacrol and biosynthesized CuO nanoparticles (NPs) with the aqueous extract of Satureja khuzestanica plant against Candida albicans and Candida tropicalis fungi. Four different modes were used to investigate the effect of fungi inactivation, aqueous extract of Satureja khuzestanica plant alone, synthesizing CuO NPs green, Carvacrol 98%, and composition of green CuO NPs and carvacrol 98%. To reduce environmental degradation effects, a simple and green approach for preparation and synthesis of nanoparticles was used. Different concentration of substances produced was applied to investigate the antifungal effects on fungal pathogens namely Candida albicans and Candida tropicalis. In this study, time-kill curve assay were determined for the experiments. Also, the studied concentrations were 1/2MIC, Minimum Inhibitory Concentration, MIC, 2MIC, 4MIC, and 8MIC. According to the obtained results, CuO NPs were spherical in shape and almost uniform in size, with an average diameter of 70 nm. The lowest concentration of MIC and Minimum Fungi Concentration (MFC) was observed in combined disinfectants Carvacrol 98%+CuO NPs. The results of analysis of variance (ANOVA) showed that there is a significant difference in the disinfecting and disinfecting power of compounds Carvacrol 98% and Carvacrol 98%+CuO NPs (Pvalue<005). In this combination, Candida tropicalis, the concentration of MIC and MFC was equal to 31 ± 25 and 52.08 ± 18.04 µg/mL, respectively. Satureja khuzestanica + CuO NPs and Carvacrol 98% was strength in Candida tropicalis in all the investigated concentrations, e.g. MIC, 2MIC, and 4MIC.