Scholarlink

<p>Heat pain thresholds (HPTs) are used for clinical assessments, sensory phenotyping, and pre–post comparisons. This usage assumes that HPTs are stable, exchangeable, and unaffected by repetition. Twenty consecutive HPT measures were taken at each volar forearm during three daily sessions in pain-free individuals. Negative exponential growth models were used to characterise HPT series and estimate effects of session, side, and time between sessions. To assess suitability for within-session pre–post comparisons, the mean of the first <i>n</i> repetitions of a series was compared with the mean of the subsequent <i>n</i> repetitions for <i>n</i> = 1–10, and ICC(3,1) calculated for <i>n</i> = 2–20. From 23 participants, 2266 HPT measurements were recorded within 118 series. Strong habituation was observed (Cohen’s <i>d</i> = 1.9), with HPT increasing by a mean of 4.9 °C across all series (95% CI: 4.4 to 5.3 °C, <i>p</i> &lt;0.001). Repeated HPTs followed an asymptotic trajectory; lower initial HPTs were associated with larger repetition-related increases, and right forearms adapted faster than left. Later sessions were associated with higher initial and asymptotic HPT values and faster adaptation. Using single or averaged HPTs for within-series pre–post comparisons consistently yielded false-positive findings, while ICC decreased as <i>n</i> increased.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Repeated heat pain threshold testing in pain-free individuals induces habituation and yields false-positive pre–post comparisons

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月16日

查看全文
  • David William Evans,
  • Victoria Frowen,
  • Michael Mansfield

摘要

Heat pain thresholds (HPTs) are used for clinical assessments, sensory phenotyping, and pre–post comparisons. This usage assumes that HPTs are stable, exchangeable, and unaffected by repetition. Twenty consecutive HPT measures were taken at each volar forearm during three daily sessions in pain-free individuals. Negative exponential growth models were used to characterise HPT series and estimate effects of session, side, and time between sessions. To assess suitability for within-session pre–post comparisons, the mean of the first n repetitions of a series was compared with the mean of the subsequent n repetitions for n = 1–10, and ICC(3,1) calculated for n = 2–20. From 23 participants, 2266 HPT measurements were recorded within 118 series. Strong habituation was observed (Cohen’s d = 1.9), with HPT increasing by a mean of 4.9 °C across all series (95% CI: 4.4 to 5.3 °C, p <0.001). Repeated HPTs followed an asymptotic trajectory; lower initial HPTs were associated with larger repetition-related increases, and right forearms adapted faster than left. Later sessions were associated with higher initial and asymptotic HPT values and faster adaptation. Using single or averaged HPTs for within-series pre–post comparisons consistently yielded false-positive findings, while ICC decreased as n increased.