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<p>This study aimed to quantify the risk of cardiovascular disease (CVD) mortality among patients with colorectal cancer (CRC) relative to the general population. We conducted a population-based cohort analysis using data from the Surveillance, Epidemiology, and End Results (SEER) program (1990–2021). A total of 201,353 CRC patients aged ≥ 30 years were identified. Poisson regression models were employed to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for CVD mortality. CRC patients demonstrated a significantly elevated risk of CVD mortality compared to the general population (IRR 1.16, 95% CI 1.14–1.17). The risk of CVD mortality reached its peak during the first month following cancer diagnosis (IRR 9.11, 95% CI 8.46–9.80). Stratified analyses revealed that younger patients faced the highest relative excess risk, particularly those in the 30–39 age group (IRR 4.87, 95% CI 2.83–8.39). The association between CRC and CVD mortality varied based on demographic and tumor features. These findings highlight a critical window of elevated cardiovascular mortality immediately following a colorectal cancer diagnosis, emphasizing the need for heightened multidisciplinary awareness of early cardiovascular vulnerability. Future prospective studies are needed to explore effective mitigative strategies.</p>

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Cardiovascular mortality associated with colorectal cancer: a population-based observational study using the SEER database

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  • 发表日期：

    2026年7月28日

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  • Lanying Chen,
  • Juecai Chen,
  • Jing Yang,
  • Chengshi Wang,
  • Hui Cao

摘要

This study aimed to quantify the risk of cardiovascular disease (CVD) mortality among patients with colorectal cancer (CRC) relative to the general population. We conducted a population-based cohort analysis using data from the Surveillance, Epidemiology, and End Results (SEER) program (1990–2021). A total of 201,353 CRC patients aged ≥ 30 years were identified. Poisson regression models were employed to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for CVD mortality. CRC patients demonstrated a significantly elevated risk of CVD mortality compared to the general population (IRR 1.16, 95% CI 1.14–1.17). The risk of CVD mortality reached its peak during the first month following cancer diagnosis (IRR 9.11, 95% CI 8.46–9.80). Stratified analyses revealed that younger patients faced the highest relative excess risk, particularly those in the 30–39 age group (IRR 4.87, 95% CI 2.83–8.39). The association between CRC and CVD mortality varied based on demographic and tumor features. These findings highlight a critical window of elevated cardiovascular mortality immediately following a colorectal cancer diagnosis, emphasizing the need for heightened multidisciplinary awareness of early cardiovascular vulnerability. Future prospective studies are needed to explore effective mitigative strategies.