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<p>Few prospective, population-based studies investigated the effect of hypertension on kidney stones. This prospective study was conducted to assess the effect of hypertension on the incidence of kidney stones in an Iranian population, using follow-up data from the Rafsanjan Cohort Study (RCS). Data from the Rafsanjan Cohort Study (RCS), which is part of the larger Prospective Epidemiological Research Studies in Iran (PERSIAN), were utilized. In the baseline phase of this study, 10,000 adults, 35 to 70 years old, were invited using the cluster sampling method. Of these, 7,453 individuals who did not report a history of kidney stone as well as related diseases at the baseline and also had a complete medical questionnaire, were included in our study. All participants were interviewed by expert interviewers and previously validated questionnaires were completed. Data were analyzed in SPSS (ver 21) and appropriate statistical tests were used to compare groups. The mean age of the participants was 49.50 ± 9.36 years, and the majority of them were female (55.8%). 23.1% of the participants had a history of hypertension. In the group of people with the history of higher mean diastolic pressure, the incidence of kidney stone disease was statistically higher than that among the other group. Furthermore, the incidence of kidney stones was highest among untreated hypertensive individuals (6.9%), followed by treated hypertensive individuals (4.2%), and lowest in non-hypertensive individuals (3.5%). The results showed that untreated hypertensive respondents had a 1.985 times higher risk of kidney stones compared to respondents with normal blood pressure. We concluded that hypertension could significantly increases the odds of kidney stone formation.</p>

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Hypertension and incidence of kidney stones: a prospective study based on the data of the Rafsanjan cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月3日

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  • Reza Vazirinejad,
  • Hassan Ahmadinia,
  • Seyed Mojtaba Heydari Khoormizi,
  • Mahdieh Jamshidi,
  • Soudeh Khanamani Falahati-pour,
  • Vahid Mohammadi-Shahrokhi,
  • Mohammad Safarian Neamatabad,
  • Vahid Mohammadi Nematabad,
  • Marjan Abbasi-Dokht-Rafsanjani

摘要

Few prospective, population-based studies investigated the effect of hypertension on kidney stones. This prospective study was conducted to assess the effect of hypertension on the incidence of kidney stones in an Iranian population, using follow-up data from the Rafsanjan Cohort Study (RCS). Data from the Rafsanjan Cohort Study (RCS), which is part of the larger Prospective Epidemiological Research Studies in Iran (PERSIAN), were utilized. In the baseline phase of this study, 10,000 adults, 35 to 70 years old, were invited using the cluster sampling method. Of these, 7,453 individuals who did not report a history of kidney stone as well as related diseases at the baseline and also had a complete medical questionnaire, were included in our study. All participants were interviewed by expert interviewers and previously validated questionnaires were completed. Data were analyzed in SPSS (ver 21) and appropriate statistical tests were used to compare groups. The mean age of the participants was 49.50 ± 9.36 years, and the majority of them were female (55.8%). 23.1% of the participants had a history of hypertension. In the group of people with the history of higher mean diastolic pressure, the incidence of kidney stone disease was statistically higher than that among the other group. Furthermore, the incidence of kidney stones was highest among untreated hypertensive individuals (6.9%), followed by treated hypertensive individuals (4.2%), and lowest in non-hypertensive individuals (3.5%). The results showed that untreated hypertensive respondents had a 1.985 times higher risk of kidney stones compared to respondents with normal blood pressure. We concluded that hypertension could significantly increases the odds of kidney stone formation.