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<p>Perioperative hypothermia is a frequent and clinically significant complication in cancer surgery. Even mild reductions in body temperature are associated with increased bleeding, infection risk, and delayed recovery, and may also affect the timely delivery of adjuvant therapy. Despite advances in perioperative temperature monitoring and warming practices, hypothermia remains common, particularly during complex oncologic procedures. We conducted a prospective observational cohort study including 230 adult patients undergoing elective cancer surgery at the King Hussein Cancer Center, Jordan. The primary outcome was unintended perioperative hypothermia, defined as a body temperature below 36&#xa0;°C. Temperature was monitored continuously during surgery and measured postoperatively upon admission to and discharge from the Post-Anesthesia Care Unit (PACU). Hypothermia was graded according to severity. Demographic and perioperative variables, including anesthesia type, recent chemotherapy or radiotherapy exposure, intraoperative fluid administration, and warming methods, were collected. Logistic regression was used to identify factors associated with intraoperative and postoperative hypothermia. Analyses of early postoperative recovery indicators were exploratory, and the study was not powered for definitive outcome inference. Intraoperative hypothermia (IOH) occurred in 34.4% of patients, whereas postoperative hypothermia (POH) occurred in 42.6%. Higher rates were observed in gastrointestinal and thoracic procedures; however, subgroup sizes were small. Lack of active warming was associated with increased odds of intraoperative hypothermia, and IOH was independently associated with POH (OR 13.1, <i>p</i> &lt; 0.0001). Forced-air warming was independently associated with lower odds of POH (OR 0.20, <i>p</i> = 0.0006). Exploratory analyses demonstrated associations between POH and poorer early recovery indicators, including longer PACU stays and higher rates of postoperative pain and delirium. In this cohort of patients undergoing cancer surgery, perioperative hypothermia remained common. Intraoperative hypothermia (IOH) and the use of active warming were independently associated with postoperative hypothermia (POH). Exploratory analyses also identified associations between postoperative hypothermia and selected early postoperative recovery indicators. Given the observational design of the study and the exploratory nature of these analyses, the findings should be interpreted as associations rather than evidence of causal relationships.</p>

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Incidence and predictors of unintended perioperative hypothermia in cancer surgery: a prospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月8日

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  • Ahmad Arraqap,
  • Ahmad Alkharabsheh,
  • Munir Shawagfeh,
  • Marwan Obaid,
  • Mahmoud I. Ramadan,
  • Laila Al-Hafez,
  • Omar Alhyari

摘要

Perioperative hypothermia is a frequent and clinically significant complication in cancer surgery. Even mild reductions in body temperature are associated with increased bleeding, infection risk, and delayed recovery, and may also affect the timely delivery of adjuvant therapy. Despite advances in perioperative temperature monitoring and warming practices, hypothermia remains common, particularly during complex oncologic procedures. We conducted a prospective observational cohort study including 230 adult patients undergoing elective cancer surgery at the King Hussein Cancer Center, Jordan. The primary outcome was unintended perioperative hypothermia, defined as a body temperature below 36 °C. Temperature was monitored continuously during surgery and measured postoperatively upon admission to and discharge from the Post-Anesthesia Care Unit (PACU). Hypothermia was graded according to severity. Demographic and perioperative variables, including anesthesia type, recent chemotherapy or radiotherapy exposure, intraoperative fluid administration, and warming methods, were collected. Logistic regression was used to identify factors associated with intraoperative and postoperative hypothermia. Analyses of early postoperative recovery indicators were exploratory, and the study was not powered for definitive outcome inference. Intraoperative hypothermia (IOH) occurred in 34.4% of patients, whereas postoperative hypothermia (POH) occurred in 42.6%. Higher rates were observed in gastrointestinal and thoracic procedures; however, subgroup sizes were small. Lack of active warming was associated with increased odds of intraoperative hypothermia, and IOH was independently associated with POH (OR 13.1, p < 0.0001). Forced-air warming was independently associated with lower odds of POH (OR 0.20, p = 0.0006). Exploratory analyses demonstrated associations between POH and poorer early recovery indicators, including longer PACU stays and higher rates of postoperative pain and delirium. In this cohort of patients undergoing cancer surgery, perioperative hypothermia remained common. Intraoperative hypothermia (IOH) and the use of active warming were independently associated with postoperative hypothermia (POH). Exploratory analyses also identified associations between postoperative hypothermia and selected early postoperative recovery indicators. Given the observational design of the study and the exploratory nature of these analyses, the findings should be interpreted as associations rather than evidence of causal relationships.