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<p>Voxel-wise analysis of serial T1-derived apparent gadolinium-based contrast agent (GBCA) concentration maps may enable assessment of delayed-phase contrast behavior, but requires spatial correspondence across time points. This study evaluated whether elastic registration (ER) improves voxel-wise temporal consistency in sparse delayed-phase apparent GBCA concentration analysis. Forty-nine participants (median age, 62 years) underwent native and dynamic T1 mapping at 2, 5, 9, and 15&#xa0;min after GBCA administration. Apparent GBCA concentration maps of the myocardium and LV blood pool were generated from T1 values with and without ER and represented using a fixed-form temporal model. Temporal consistency was evaluated using voxel-wise fitting metrics, including the coefficient of determination (R<sup>2</sup>) and differences between measured and model-represented apparent concentrations. Phantom experiments confirmed linearity between reference and T1-derived GBCA concentrations (R<sup>2</sup> = 0.999). In vivo analysis showed that, ER improved myocardial voxel-wise R<sup>2</sup> from 0.795 to 0.816 (<i>p</i> = 0.004) and LV blood-pool R<sup>2</sup> from 0.847 to 0.902 (<i>p</i> &lt; 0.001). ER also reduced residual variability and residual error metrics, although small time-dependent mean differences remained. ER may improve voxel-wise temporal consistency of sparse delayed-phase apparent GBCA concentration analysis across serial T1 maps.</p>

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Estimation of myocardial and blood gadolinium concentrations from T1 mapping via pharmacokinetic modeling: influence of elastic deformation registration

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月2日

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  • Yasutoshi Ohta,
  • Masaru Shiotani,
  • Yoshiaki Morita,
  • Tatsuya Nishii,
  • Hiroki Horinouchi,
  • Akiyuki Kotoku,
  • Midori Fukuyama,
  • Emi Tateishi,
  • Tetsuya Fukuda

摘要

Voxel-wise analysis of serial T1-derived apparent gadolinium-based contrast agent (GBCA) concentration maps may enable assessment of delayed-phase contrast behavior, but requires spatial correspondence across time points. This study evaluated whether elastic registration (ER) improves voxel-wise temporal consistency in sparse delayed-phase apparent GBCA concentration analysis. Forty-nine participants (median age, 62 years) underwent native and dynamic T1 mapping at 2, 5, 9, and 15 min after GBCA administration. Apparent GBCA concentration maps of the myocardium and LV blood pool were generated from T1 values with and without ER and represented using a fixed-form temporal model. Temporal consistency was evaluated using voxel-wise fitting metrics, including the coefficient of determination (R2) and differences between measured and model-represented apparent concentrations. Phantom experiments confirmed linearity between reference and T1-derived GBCA concentrations (R2 = 0.999). In vivo analysis showed that, ER improved myocardial voxel-wise R2 from 0.795 to 0.816 (p = 0.004) and LV blood-pool R2 from 0.847 to 0.902 (p < 0.001). ER also reduced residual variability and residual error metrics, although small time-dependent mean differences remained. ER may improve voxel-wise temporal consistency of sparse delayed-phase apparent GBCA concentration analysis across serial T1 maps.